Tclin HCN3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Protein Summary

Description

Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q9P1Z3
• D3DV90
• Q4VX12
• Q8N6W6
• Q9BWQ2

Gene Name

• HCN3

Ensembl ID

• ENST00000368358
• ENSP00000357342
• ENSG00000143630
• ENST00000575670
• ENSP00000458364
• ENSG00000263324

Symbol

• KIAA1535

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
virus perturbation	0.99
protein domain	0.85
cell line	0.61
transcription factor binding site profile	0.61

Protein Classes

DTO Classes

Protein / Ion Channel / Cyclic Nucleotide-gated Cation Channel Family / Potassium/sodium Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.15   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 274   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.15   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2