Tbio HCLS1 Hematopoietic lineage cell-specific protein

Protein Summary

Description

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

Uniprot Accession IDs

• P14317
• B4DQ69
• Q53Y93
• Q6IBK9
• Q9UDK0

Gene Name

• HCLS1

Ensembl ID

• ENST00000314583
• ENSP00000320176
• ENSG00000180353
• ENST00000495491
• ENSP00000418299

Symbol

• HS1
• HS1
• p75
• CTTNL
• lckBP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.87
gene perturbation	0.81
kinase	0.78
virus perturbation	0.76
hub protein	0.71

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Hematopoietic Lineage Cell-specific Protein

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Hematopoietic Lineage Cell-specific Protein

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Hematopoietic Lineage Cell-specific Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.92   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 428   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.92   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0