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Tclin
HCK
Tyrosine-protein kinase HCK

Protein Summary
Description
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000518730
  • ENSP00000427757
  • ENSG00000101336
  • ENST00000520553
  • ENSP00000429848
  • ENST00000534862
  • ENSP00000444986
  • ENST00000538448
  • ENSP00000441169
  • ENST00000629881
  • ENSP00000486627
  • ENST00000639405
  • ENSP00000491964

Symbol
  • JTK9
  • p59Hck
  • p61Hck
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
PubMedID
0.99
biological process
0.98
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.47   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.47   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 116
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4