Tbio HCFC2 Host cell factor 2

Protein Summary

Description

This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5Z7
• B2R8Q5
• C0H5X3
• HCF-2

Gene Name

• HCFC2

Ensembl ID

• ENST00000229330
• ENSP00000229330
• ENSG00000111727
• ENST00000544223
• ENSP00000442942

Symbol

• HCF2
• HCF-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.91
histone modification site profile	0.85
virus perturbation	0.85
interacting protein	0.82
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0