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Tbio
HCFC1R1
Host cell factor C1 regulator 1

Protein Summary
Description
Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248089
  • ENSP00000248089
  • ENSG00000103145
  • ENST00000574151
  • ENSP00000459178
  • ENST00000574980
  • ENSP00000460639

Symbol
  • HPIP
  • HPIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
transcription factor binding site profile
0.92
kinase perturbation
0.81
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
HCFC1
Tbio
Novelty:  0.00440762
p_int:  0.967319043
p_ni:  0.032680957
Score:  0.379
Data Source:  BioPlex,STRINGDB
OGT
Tchem
Family:  Enzyme
Novelty:  0.00290822
p_int:  0.891147665
p_ni:  0.108852335
Score:  0.269
Data Source:  BioPlex,STRINGDB
NUFIP2
Tbio
Novelty:  0.09366649
Score:  0.59
Data Source:  STRINGDB
NME3
Tbio
Family:  Kinase
Novelty:  0.05947052
Score:  0.577
Data Source:  STRINGDB
C1QTNF12
Tbio
Novelty:  0.0694377
Score:  0.542
Data Source:  STRINGDB
FAM166A
Tdark
Novelty:  32.79136691
Score:  0.53
Data Source:  STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
Score:  0.524
Data Source:  STRINGDB
TMEM214
Tdark
Novelty:  0.32604613
Score:  0.51
Data Source:  STRINGDB
E4F1
Tbio
Family:  TF
Novelty:  0.02192338
Score:  0.462
Data Source:  STRINGDB
TMEM167A
Tdark
Novelty:  0.57799292
Score:  0.46
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
1
56.7
serum alanine aminotransferase measurement
1
1
1
22.5
brain measurement
1
1
0
5.8
18.4
balding measurement
1
1
1
17.6
sex hormone-binding globulin measurement
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
56.7
serum alanine aminotransferase measurement
1
22.5
brain measurement
0
5.8
18.4
balding measurement
1
17.6
sex hormone-binding globulin measurement
1
3.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
host cell factor C1 regulator 1
VGNC:9081
453853
Macaque
host cell factor C1 regulator 1
700351
Mouse
MGI:2663619
353502
Rat
RGD:727975
287097
Dog
host cell factor C1 regulator 1
VGNC:41616
610727
Species
Name
OMA
EggNOG
Inparanoid
Chimp
host cell factor C1 regulator 1
Macaque
host cell factor C1 regulator 1
Mouse
Rat
Dog
host cell factor C1 regulator 1
Publication Statistics
PubMed Score 0.31
PubMed score by year
PubTator Score 1.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title