Protein Summary
Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 ...more
- ENST00000310441
- ENSP00000309555
- ENSG00000172534
- HCF1
- HFC1
- CFF
- HCF
- HCF1
- HFC1
- MRX3
- VCAF
- HCF-1
- PPP1R89
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.97 | ||
molecular function | 0.91 | ||
biological process | 0.85 | ||
cellular component | 0.8 | ||
hub protein | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 241.14 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 230 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 241.14 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 230 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (187)
THAP3
Family: TF
Novelty: 0.52942342
p_int: 0.99931263
p_ni: 0.00068737
Score: 0.752
Data Source: BioPlex,STRINGDB
DIDO1
Family: Epigenetic
Novelty: 0.0492858
p_int: 0.999301829
p_ni: 0.000698172
Score: 0.241
Data Source: BioPlex,STRINGDB
BAP1
Family: Enzyme
Novelty: 0.00501435
p_int: 0.99682577
p_ni: 0.003174231
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
CREB3
Family: TF
Novelty: 0.00424318
p_int: 0.992460217
p_ni: 0.007539783
Score: 0.854
Data Source: BioPlex,STRINGDB
THAP11
Family: TF
Novelty: 0.0679686
p_int: 0.98662303
p_ni: 0.01337697
Score: 0.87
Data Source: BioPlex,STRINGDB
HCFC2
Novelty: 0.12260416
p_int: 0.975211488
p_ni: 0.024788512
Score: 0.957
Data Source: BioPlex,STRINGDB
DDAH2
Family: Enzyme
Novelty: 0.00355931
p_int: 0.972458567
p_ni: 0.027541433
Score: 0.228
Data Source: BioPlex,STRINGDB
SENP5
Family: Enzyme
Novelty: 0.0510532
p_int: 0.968005444
p_ni: 0.031994556
Data Source: BioPlex
HCFC1R1
Novelty: 2.97633658
p_int: 0.967319043
p_ni: 0.032680957
Score: 0.379
Data Source: BioPlex,STRINGDB
CAMK2D
Family: Kinase
Novelty: 0.02326864
p_int: 0.873293989
p_ni: 0.126706011
Score: 0.212
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (12)
Reactome (10)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Deubiquitination | ||||
Reactome | HATs acetylate histones | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Deubiquitination | ||||
HATs acetylate histones | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (9)
Components (11)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.2 | 77.6 | |||||
3 | 3 | 0 | 1.6 | 77.2 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 75.5 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 74.4 | |||||
albumin:globulin ratio measurement | 1 | 1 | 1 | 36.9 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 77.6 | |||||
0 | 1.6 | 77.2 | |||||
neutrophil percentage of leukocytes | 1 | 75.5 | |||||
lymphocyte percentage of leukocytes | 1 | 74.4 | |||||
albumin:globulin ratio measurement | 1 | 36.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | host cell factor C1 | VGNC:12398 | 465933 | |||||
Mouse | MGI:105942 | 15161 | ||||||
Rat | RGD:1563804 | 363519 | ||||||
Dog | host cell factor C1 | VGNC:41615 | 492246 | |||||
Horse | host cell factor C1 | VGNC:18707 | 100058080 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | host cell factor C1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | host cell factor C1 | |||||
Horse | host cell factor C1 | |||||
Publication Statistics
PubMed Score 241.14
PubMed score by year
PubTator Score 2434.70
PubTator score by year
Related Publications
Text Mined References (93)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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