Tbio HCFC1 Host cell factor 1

Protein Summary

Description

Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51610
• Q6P4G5
• HCF

Gene Name

• HCFC1

Ensembl ID

• ENST00000310441
• ENSP00000309555
• ENSG00000172534

Symbol

• HCF1
• HFC1
• CFF
• HCF
• HCF1
• HFC1
• MRX3
• VCAF
• HCF-1
• PPP1R89

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
molecular function	0.91
biological process	0.85
cellular component	0.8
hub protein	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.14   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 230   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.14   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (187)

Explore Interacting Targets

1 – 10 of 187

• See Interactions on String-DB

THAP3

Tdark

Family:  TF

Novelty:  0.52942342

p_int:  0.99931263

p_ni:  0.00068737

Score:  0.752

Data Source:  BioPlex,STRINGDB

DIDO1

Tbio

Family:  Epigenetic

Novelty:  0.0492858

p_int:  0.999301829

p_ni:  0.000698172

Score:  0.241

Data Source:  BioPlex,STRINGDB

BAP1

Tbio

Family:  Enzyme

Novelty:  0.00501435

p_int:  0.99682577

p_ni:  0.003174231

Score:  0.989

Data Source:  BioPlex,Reactome,STRINGDB

CREB3

Tbio

Family:  TF

Novelty:  0.00424318

p_int:  0.992460217

p_ni:  0.007539783

Score:  0.854

Data Source:  BioPlex,STRINGDB

THAP11

Tbio

Family:  TF

Novelty:  0.0679686

p_int:  0.98662303

p_ni:  0.01337697

Score:  0.87

Data Source:  BioPlex,STRINGDB

HCFC2

Tbio

Novelty:  0.12260416

p_int:  0.975211488

p_ni:  0.024788512

Score:  0.957

Data Source:  BioPlex,STRINGDB

DDAH2

Tbio

Family:  Enzyme

Novelty:  0.00355931

p_int:  0.972458567

p_ni:  0.027541433

Score:  0.228

Data Source:  BioPlex,STRINGDB

SENP5

Tbio

Family:  Enzyme

Novelty:  0.0510532

p_int:  0.968005444

p_ni:  0.031994556

Data Source:  BioPlex

HCFC1R1

Tbio

Novelty:  2.97633658

p_int:  0.967319043

p_ni:  0.032680957

Score:  0.379

Data Source:  BioPlex,STRINGDB

CAMK2D

Tchem

Family:  Kinase

Novelty:  0.02326864

p_int:  0.873293989

p_ni:  0.126706011

Score:  0.212

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (12)

Reactome (10)

KEGG (1)

WikiPathways (1)

Chromatin modifying enzymes (R-HSA-3247509)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	Deubiquitination	278 targets	R-HSA-5688426
Reactome	HATs acetylate histones	107 targets	R-HSA-3214847
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
Deubiquitination	278 targets	R-HSA-5688426
HATs acetylate histones	107 targets	R-HSA-3214847
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (37)

Functions (9)

Components (11)

Processes (17)

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1 – 9 of 9

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB
activating transcription factor binding	Inferred from Physical Interaction (IPI)	CAFA
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein binding, bridging	Inferred from Physical Interaction (IPI)	UniProtKB
transcription coactivator activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
DNA-binding transcription factor activity	Non-traceable Author Statement (NAS)	ProtInc
distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl
sequence-specific double-stranded DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (11)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
rheumatoid arthritis	EFO_0000685	2	2	0	1.2	77.6
systemic lupus erythematosus	EFO_0002690	3	3	0	1.6	77.2
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		75.5
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		74.4
albumin:globulin ratio measurement	EFO_0005128	1	1	1		36.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
rheumatoid arthritis	EFO_0000685	0	1.2	77.6
systemic lupus erythematosus	EFO_0002690	0	1.6	77.2
neutrophil percentage of leukocytes	EFO_0007990	1		75.5
lymphocyte percentage of leukocytes	EFO_0007993	1		74.4
albumin:globulin ratio measurement	EFO_0005128	1		36.9

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Autocatalytic cleavage
Cell cycle
Chromatin regulator
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation

GWAS Trait Find Similar Targets

No Header	No Header
albumin:globulin ratio measurement
celiac disease
lymphocyte count
lymphocyte percentage of leukocytes
mean reticulocyte volume
neutrophil percentage of leukocytes
rheumatoid arthritis
schizophrenia
serum non-albumin protein measurement
snoring measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
growth/size/body region phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	host cell factor C1	VGNC:12398	465933
Mouse	host cell factor C1	MGI:105942	15161
Rat	host cell factor C1	RGD:1563804	363519
Dog	host cell factor C1	VGNC:41615	492246
Horse	host cell factor C1	VGNC:18707	100058080

Species	Name	OMA	EggNOG	Inparanoid
Chimp	host cell factor C1
Mouse	host cell factor C1
Rat	host cell factor C1
Dog	host cell factor C1
Horse	host cell factor C1

Publication Statistics

PubMed Score 241.14

PubMed score by year

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PubTator Score 2434.70

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Related Publications

Text Mined References (93)

GeneRif Annotations (42)

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PMID	Year	Title