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Tbio
HCCS
Cytochrome c-type heme lyase

Protein Summary
Description
Links covalently the heme group to the apoprotein of cytochrome c. The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321143
  • ENSP00000326579
  • ENSG00000004961
  • ENST00000380762
  • ENSP00000370139
  • ENST00000380763
  • ENSP00000370140

Symbol
  • CCHL
  • MLS
  • CCHL
  • MCOPS7
  • LSDMCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor perturbation
0.91
co-expressed gene
0.87
disease perturbation
0.87
histone modification site profile
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.44   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.44   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0