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Tbio
HBS1L
HBS1-like protein

Protein Summary
Description
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367822
  • ENSP00000356796
  • ENSG00000112339
  • ENST00000367826
  • ENSP00000356800
  • ENST00000367837
  • ENSP00000356811

Symbol
  • HBS1
  • KIAA1038
  • ERFS
  • HBS1
  • EF-1a
  • eRF3c
  • HSPC276
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
molecular function
0.95
protein domain
0.92
interacting protein
0.88
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.21   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 794.21   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (262)
EXOSC3
Tbio
Novelty:  0.03072164
p_int:  0.999987314
p_ni:  0.000012686
Score:  0.997
Data Source:  BioPlex,STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
p_int:  0.999905596
p_ni:  0.000094404
Score:  0.996
Data Source:  BioPlex,STRINGDB
CACNG2
Tbio
Family:  IC
Novelty:  0.00808502
p_int:  0.999757836
p_ni:  0.000242164
Score:  0.179
Data Source:  BioPlex,STRINGDB
C11orf87
Tdark
Novelty:  1.33249342
p_int:  0.999728008
p_ni:  0.000271992
Data Source:  BioPlex
STK25
Tchem
Family:  Kinase
Novelty:  0.03229688
p_int:  0.998235628
p_ni:  0.001764372
Score:  0.159
Data Source:  BioPlex,STRINGDB
EXOSC1
Tbio
Novelty:  0.01386842
p_int:  0.995091376
p_ni:  0.004908624
Score:  0.997
Data Source:  BioPlex,STRINGDB
EXOSC8
Tbio
Family:  Enzyme
Novelty:  0.02013403
p_int:  0.99095383
p_ni:  0.00904617
Score:  0.997
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.978653742
p_ni:  0.021346255
p_wrong:  3e-9
Score:  0.42
Data Source:  BioPlex,STRINGDB
ISOC2
Tbio
Family:  Enzyme
Novelty:  0.33841868
p_int:  0.956729798
p_ni:  0.043270202
Data Source:  BioPlex
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
p_int:  0.951763133
p_ni:  0.048236867
Score:  0.337
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
mRNA decay by 3' to 5' exoribonuclease
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
mRNA decay by 3' to 5' exoribonuclease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
13
12
9
6
99.9
mean corpuscular volume
10
12
15
99.8
erythrocyte count
9
11
13
99.8
mean corpuscular hemoglobin concentration
11
9
14
99.8
hematocrit
9
8
11
99.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
9
6
99.9
mean corpuscular volume
15
99.8
erythrocyte count
13
99.8
mean corpuscular hemoglobin concentration
14
99.8
hematocrit
11
99.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HBS1 like translational GTPase
VGNC:2856
463015
Macaque
HBS1 like translational GTPase
706748
Mouse
MGI:1891704
56422
Rat
RGD:1308509
293408
Dog
HBS1 like translational GTPase
VGNC:41612
476211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HBS1 like translational GTPase
Macaque
HBS1 like translational GTPase
Mouse
Rat
Dog
HBS1 like translational GTPase
Publication Statistics
PubMed Score 794.21
PubMed score by year
PubTator Score 83.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text