Tbio HBQ1 Hemoglobin subunit theta-1

Protein Summary

Description

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09105
• Q13723
• Q1W6G5

Gene Name

• HBQ1

Ensembl ID

• ENST00000199708
• ENSP00000199708
• ENSG00000086506

Symbol

• HBQ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
cell type or tissue	0.57
co-expressed gene	0.57
molecular function	0.56
transcription factor binding site profile	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.67   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.67   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0