Tbio HBP1 HMG box-containing protein 1

Protein Summary

Description

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

Uniprot Accession IDs

• O60381
• B3KVB7
• Q8TBM1
• Q8TE93
• Q96AJ2

Gene Name

• HBP1

Ensembl ID

• ENST00000222574
• ENSP00000222574
• ENSG00000105856
• ENST00000468410
• ENSP00000420500
• ENST00000485846
• ENSP00000418738
• ENST00000638303
• ENSP00000491311
• ENSG00000283847
• ENST00000638893
• ENSP00000492167
• ENST00000640195
• ENSP00000492343

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.98
transcription factor perturbation	0.94
virus perturbation	0.9
disease perturbation	0.87
histone modification site profile	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.41   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.41   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0