Tdark HBM Hemoglobin subunit mu

Protein Summary

Description

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6B0K9

Gene Name

• HBM

Ensembl ID

• ENST00000356815
• ENSP00000349270
• ENSG00000206177

Symbol

• HBAP2
• HBK
• HBAP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
molecular function	0.53
metabolite	0.45
tissue	0.43
cellular component	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.64   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.64   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

• See Interactions on String-DB

MUC5B

Tbio

Novelty:  0.000832

p_int:  0.999997697

p_ni:  0.000002303

Score:  0.175

Data Source:  BioPlex,STRINGDB

SCGB2A1

Tbio

Novelty:  0.01902973

p_int:  0.999995207

p_ni:  0.000004791

p_wrong:  2e-9

Score:  0.179

Data Source:  BioPlex,STRINGDB

BPIFB1

Tbio

Novelty:  0.03980683

p_int:  0.999986615

p_ni:  0.000013385

Score:  0.183

Data Source:  BioPlex,STRINGDB

MUC5AC

Tbio

Novelty:  0.00074159

p_int:  0.999977616

p_ni:  6.65e-7

p_wrong:  0.000021719

Score:  0.26

Data Source:  BioPlex,STRINGDB

IGHA2

Tbio

p_int:  0.999874717

p_ni:  0.000124979

p_wrong:  3.04e-7

Data Source:  BioPlex

LTF

Tbio

Novelty:  0.00114254

p_int:  0.999801173

p_ni:  0.000198827

Score:  0.2

Data Source:  BioPlex,STRINGDB

BPIFA1

Tbio

Novelty:  0.00586117

p_int:  0.999766769

p_ni:  0.000127855

p_wrong:  0.000105376

Score:  0.163

Data Source:  BioPlex,STRINGDB

PIGR

Tbio

Novelty:  0.0025812

p_int:  0.999691918

p_ni:  0.000308078

p_wrong:  5e-9

Data Source:  BioPlex

PRR4

Tbio

Novelty:  0.01240966

p_int:  0.999174233

p_ni:  0.00003703

p_wrong:  0.000788737

Score:  0.189

Data Source:  BioPlex,STRINGDB

LACRT

Tbio

Novelty:  0.03333799

p_int:  0.998293907

p_ni:  0.001706093

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (5)

Components (2)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
heme binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
organic acid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oxygen binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oxygen carrier activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (22)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 22

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	13	19	26		99.9
mean corpuscular volume	EFO_0004526	6	11	14		98.7
mean corpuscular hemoglobin	EFO_0004527	4	6	6		98.6
erythrocyte count	EFO_0004305	7	12	17		98.4
reticulocyte measurement	EFO_0010700	3	13	18		98.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 22

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	26		99.9
mean corpuscular volume	EFO_0004526	14		98.7
mean corpuscular hemoglobin	EFO_0004527	6		98.6
erythrocyte count	EFO_0004305	17		98.4
reticulocyte measurement	EFO_0010700	18		98.3

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Heme
Iron
Metal-binding
Oxygen transport
Reference proteome
Transport

GWAS Trait Find Similar Targets

No Header	No Header
bilirubin measurement
central nervous system cancer
erythrocyte count
erythrocyte measurement
glioblastoma multiforme
HbA1c measurement
heel bone mineral density
hematocrit
hematological measurement
hemoglobin A1 measurement

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	hemoglobin subunit mu	VGNC:5781	100608451
Dog	hemoglobin subunit mu	VGNC:41610	100855616
Cow	hemoglobin subunit mu	VGNC:29766	100140603
Pig	hemoglobin subunit mu		100737727

Species	Name	OMA	EggNOG	Inparanoid
Chimp	hemoglobin subunit mu
Dog	hemoglobin subunit mu
Cow	hemoglobin subunit mu
Pig	hemoglobin subunit mu

Publication Statistics

PubMed Score 36.64

PubMed score by year

Reset Zoom

PubTator Score 22.11

PubTator score by year

Reset Zoom

Related Publications

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Text