Protein Summary
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]
- ENST00000356815
- ENSP00000349270
- ENSG00000206177
- HBAP2
- HBK
- HBAP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.58 | ||
molecular function | 0.53 | ||
metabolite | 0.45 | ||
tissue | 0.43 | ||
cellular component | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.64 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 29 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.64 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 29 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (36)
MUC5B
Novelty: 0.000832
p_int: 0.999997697
p_ni: 0.000002303
Score: 0.175
Data Source: BioPlex,STRINGDB
SCGB2A1
Novelty: 0.01902973
p_int: 0.999995207
p_ni: 0.000004791
p_wrong: 2e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
BPIFB1
Novelty: 0.03980683
p_int: 0.999986615
p_ni: 0.000013385
Score: 0.183
Data Source: BioPlex,STRINGDB
MUC5AC
Novelty: 0.00074159
p_int: 0.999977616
p_ni: 6.65e-7
p_wrong: 0.000021719
Score: 0.26
Data Source: BioPlex,STRINGDB
LTF
Novelty: 0.00114254
p_int: 0.999801173
p_ni: 0.000198827
Score: 0.2
Data Source: BioPlex,STRINGDB
BPIFA1
Novelty: 0.00586117
p_int: 0.999766769
p_ni: 0.000127855
p_wrong: 0.000105376
Score: 0.163
Data Source: BioPlex,STRINGDB
PRR4
Novelty: 0.01240966
p_int: 0.999174233
p_ni: 0.00003703
p_wrong: 0.000788737
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (5)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 13 | 19 | 26 | 99.9 | |||||
mean corpuscular volume | 6 | 11 | 14 | 98.7 | |||||
mean corpuscular hemoglobin | 4 | 6 | 6 | 98.6 | |||||
erythrocyte count | 7 | 12 | 17 | 98.4 | |||||
reticulocyte measurement | 3 | 13 | 18 | 98.3 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 26 | 99.9 | |||||
mean corpuscular volume | 14 | 98.7 | |||||
mean corpuscular hemoglobin | 6 | 98.6 | |||||
erythrocyte count | 17 | 98.4 | |||||
reticulocyte measurement | 18 | 98.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | hemoglobin subunit mu | VGNC:5781 | 100608451 | |||||
Dog | hemoglobin subunit mu | VGNC:41610 | 100855616 | |||||
Cow | hemoglobin subunit mu | VGNC:29766 | 100140603 | |||||
Pig | hemoglobin subunit mu | 100737727 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | hemoglobin subunit mu | |||||
Dog | hemoglobin subunit mu | |||||
Cow | hemoglobin subunit mu | |||||
Pig | hemoglobin subunit mu | |||||
Publication Statistics
PubMed Score 36.64
PubMed score by year
PubTator Score 22.11
PubTator score by year
Related Publications
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Text |
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