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Tdark
HBM
Hemoglobin subunit mu

Protein Summary
Description
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is similar to the delta globins found in reptiles and birds. This locus was originally described as a pseudogene; however, it is currently thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356815
  • ENSP00000349270
  • ENSG00000206177

Symbol
  • HBAP2
  • HBK
  • HBAP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
molecular function
0.53
metabolite
0.45
tissue
0.43
cellular component
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
MUC5B
Tbio
Novelty:  0.000832
p_int:  0.999997697
p_ni:  0.000002303
Score:  0.175
Data Source:  BioPlex,STRINGDB
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.999995207
p_ni:  0.000004791
p_wrong:  2e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
BPIFB1
Tbio
Novelty:  0.03980683
p_int:  0.999986615
p_ni:  0.000013385
Score:  0.183
Data Source:  BioPlex,STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
p_int:  0.999977616
p_ni:  6.65e-7
p_wrong:  0.000021719
Score:  0.26
Data Source:  BioPlex,STRINGDB
IGHA2
Tbio
p_int:  0.999874717
p_ni:  0.000124979
p_wrong:  3.04e-7
Data Source:  BioPlex
LTF
Tbio
Novelty:  0.00114254
p_int:  0.999801173
p_ni:  0.000198827
Score:  0.2
Data Source:  BioPlex,STRINGDB
BPIFA1
Tbio
Novelty:  0.00586117
p_int:  0.999766769
p_ni:  0.000127855
p_wrong:  0.000105376
Score:  0.163
Data Source:  BioPlex,STRINGDB
PIGR
Tbio
Novelty:  0.0025812
p_int:  0.999691918
p_ni:  0.000308078
p_wrong:  5e-9
Data Source:  BioPlex
PRR4
Tbio
Novelty:  0.01240966
p_int:  0.999174233
p_ni:  0.00003703
p_wrong:  0.000788737
Score:  0.189
Data Source:  BioPlex,STRINGDB
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.998293907
p_ni:  0.001706093
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
13
19
26
99.9
mean corpuscular volume
6
11
14
98.7
mean corpuscular hemoglobin
4
6
6
98.6
erythrocyte count
7
12
17
98.4
reticulocyte measurement
3
13
18
98.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
26
99.9
mean corpuscular volume
14
98.7
mean corpuscular hemoglobin
6
98.6
erythrocyte count
17
98.4
reticulocyte measurement
18
98.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit mu
VGNC:5781
100608451
Dog
hemoglobin subunit mu
VGNC:41610
100855616
Cow
hemoglobin subunit mu
VGNC:29766
100140603
Pig
hemoglobin subunit mu
100737727
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit mu
Dog
hemoglobin subunit mu
Cow
hemoglobin subunit mu
Pig
hemoglobin subunit mu
Publication Statistics
PubMed Score 36.64
PubMed score by year
PubTator Score 22.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text