Tbio HBEGF Proheparin-binding EGF-like growth factor

Protein Summary

Description

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Uniprot Accession IDs

• Q99075
• B2R821

Gene Name

• HBEGF

Ensembl ID

• ENST00000230990
• ENSP00000230990
• ENSG00000113070

Symbol

• DTR
• DTS
• HEGFL
• DTR
• DTS
• DTSF
• HEGFL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
PubMedID	0.94
kinase perturbation	0.93
gene perturbation	0.92
small molecule perturbation	0.92

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Proheparin-binding Egf-like Growth Factor

DTO Classes

Protein / Signaling / Growth Factor / Proheparin-binding Egf-like Growth Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1168.22   (req: < 5)

Gene RIFs: 162   (req: <= 3)

Antibodies: 368   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1168.22   (req: >= 5)

Gene RIFs: 162   (req: > 3)

Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0