You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HBE1
Hemoglobin subunit epsilon

Protein Summary
Description
The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292896
  • ENSP00000292896
  • ENSG00000213931
  • ENST00000380237
  • ENSP00000369586
  • ENST00000396895
  • ENSP00000380104

Symbol
  • HBE
  • HBE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.8
interacting protein
0.75
molecular function
0.63
cell type or tissue
0.62
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 828.04   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 828.04   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
MACROD1
Tchem
Family:  Enzyme
Novelty:  0.03610474
p_int:  0.853973949
p_wrong:  0.146026051
Score:  0.391
Data Source:  BioPlex,STRINGDB
HBA1
Tclin
Novelty:  0.00094113
Score:  0.996
Data Source:  STRINGDB
HBZ
Tbio
Novelty:  0.00331625
Score:  0.996
Data Source:  STRINGDB
HBG1
Tbio
Novelty:  0.00384136
Score:  0.965
Data Source:  STRINGDB
HBQ1
Tbio
Novelty:  0.00951181
Score:  0.952
Data Source:  STRINGDB
NFE2
Tchem
Family:  TF
Novelty:  0.00321017
Score:  0.942
Data Source:  STRINGDB
HBG2
Tbio
Novelty:  0.01145628
Score:  0.931
Data Source:  STRINGDB
AHSP
Tbio
Novelty:  0.00996928
Score:  0.925
Data Source:  STRINGDB
HBD
Tbio
Novelty:  0.00203187
Score:  0.911
Data Source:  STRINGDB
MAFG
Tbio
Family:  TF
Novelty:  0.01605125
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
7
7
97.9
mean corpuscular hemoglobin concentration
5
3
5
95.7
mean corpuscular volume
2
3
3
94.5
HbA1c measurement
5
3
5
94.4
mean reticulocyte volume
1
2
2
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
97.9
mean corpuscular hemoglobin concentration
5
95.7
mean corpuscular volume
3
94.5
HbA1c measurement
5
94.4
mean reticulocyte volume
2
88
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit epsilon 1
VGNC:3254
100190972
Mouse
MGI:96027
15135
Rat
RGD:1305115
293267
Horse
hemoglobin subunit epsilon
100068926
Cow
hemoglobin, epsilon 1
539994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit epsilon 1
Mouse
Rat
Horse
hemoglobin subunit epsilon
Cow
hemoglobin, epsilon 1
Publication Statistics
PubMed Score 828.04
PubMed score by year
PubTator Score 262.16
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Text