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Tbio
HBB
Hemoglobin subunit beta

Protein Summary
Description
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
cell type or tissue
0.97
phenotype
0.95
PubMedID
0.9
cellular component
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1996.92   (req: < 5)
Gene RIFs: 382   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1996.92   (req: >= 5)
Gene RIFs: 382   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (184)
UPF3A
Tbio
Novelty:  0.01431609
p_int:  0.999999906
p_ni:  9.4e-8
Score:  0.395
Data Source:  BioPlex,STRINGDB
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.99999959
p_ni:  4.1e-7
Data Source:  BioPlex
MAPK6
Tbio
Family:  Kinase
Novelty:  0.01012514
p_int:  0.99974036
p_ni:  0.000256272
p_wrong:  0.000003368
Data Source:  BioPlex
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.999533557
p_ni:  0.000466443
Data Source:  BioPlex
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.999363987
p_ni:  0.000636013
Data Source:  BioPlex
MSL2
Tbio
Family:  Enzyme
Novelty:  0.01221658
p_int:  0.999352675
p_ni:  0.000647325
Score:  0.175
Data Source:  BioPlex,STRINGDB
PNKP
Tchem
Family:  Enzyme
Novelty:  0.01038571
p_int:  0.999134871
p_ni:  0.000865129
Score:  0.187
Data Source:  BioPlex,STRINGDB
DHRS2
Tbio
Family:  Enzyme
Novelty:  0.002032
p_int:  0.998399548
p_ni:  0.001600451
Score:  0.198
Data Source:  BioPlex,STRINGDB
PLXNB1
Tbio
Novelty:  0.01073808
p_int:  0.997697138
p_ni:  0.002302857
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
GSTT1
Tbio
Family:  Enzyme
p_int:  0.997444829
p_ni:  0.002555171
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Chaperone Mediated Autophagy
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
Erythrocytes take up oxygen and release carbon dioxide
Name
Explore in Pharos
Explore in Source
Autophagy
Binding and Uptake of Ligands by Scavenger Receptors
Chaperone Mediated Autophagy
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
7
7
97.9
mean corpuscular hemoglobin concentration
6
4
6
96.2
HbA1c measurement
5
3
5
94.4
mean corpuscular volume
3
3
2
1.1
93.2
mean reticulocyte volume
1
1
1
76.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
97.9
mean corpuscular hemoglobin concentration
6
96.2
HbA1c measurement
5
94.4
mean corpuscular volume
2
1.1
93.2
mean reticulocyte volume
1
76.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit beta
VGNC:3255
450978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit beta
Publication Statistics
PubMed Score 1996.92
PubMed score by year
PubTator Score 887.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text