Protein Summary
Involved in oxygen transport from the lung to the various peripheral tissues. The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]
- ENST00000251595
- ENSP00000251595
- ENSG00000188536
- ENST00000320868
- ENSP00000322421
- ENSG00000206172
- HBH
- ECYT7
- HBA-T3
- METHBA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
small molecule perturbation | 1 | ||
cellular component | 0.99 | ||
interacting protein | 0.96 | ||
biological term | 0.85 | ||
cell type or tissue | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 952.28 (req: < 5)
Gene RIFs: 239 (req: <= 3)
Antibodies: 168 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 952.28 (req: >= 5)
Gene RIFs: 239 (req: > 3)
Antibodies: 168 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (127)
GDPD1
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999963934
p_ni: 0.000036066
Data Source: BioPlex
MAPK6
Family: Kinase
Novelty: 0.01012514
p_int: 0.998292985
p_ni: 0.00170691
p_wrong: 1.05e-7
Data Source: BioPlex
TNFSF8
Novelty: 0.01292216
p_int: 0.997937592
p_ni: 0.002062354
p_wrong: 5.4e-8
Data Source: BioPlex
FCGR1A
Novelty: 0.00073204
p_int: 0.995277328
p_ni: 0.004722661
p_wrong: 1.2e-8
Data Source: BioPlex
IGSF8
Novelty: 0.03016623
p_int: 0.994241471
p_ni: 0.00575843
p_wrong: 9.9e-8
Data Source: BioPlex
MSL2
Family: Enzyme
Novelty: 0.01221658
p_int: 0.991115363
p_ni: 0.008884633
p_wrong: 4e-9
Data Source: BioPlex
HSPA8
Novelty: 0.00081014
p_int: 0.985787962
p_ni: 0.014212036
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (13)
Reactome (7)
KEGG (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
Reactome | Erythrocytes take up oxygen and release carbon dioxide | ||||
Reactome | O2/CO2 exchange in erythrocytes | ||||
Reactome | Scavenging of heme from plasma | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Erythrocytes take up carbon dioxide and release oxygen | ||||
Erythrocytes take up oxygen and release carbon dioxide | ||||
O2/CO2 exchange in erythrocytes | ||||
Scavenging of heme from plasma | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (5)
Components (10)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (42)
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 13 | 19 | 26 | 99.9 | ||||||
mean corpuscular hemoglobin concentration | 13 | 19 | 26 | 99.9 | ||||||
mean corpuscular volume | 6 | 11 | 14 | 98.7 | ||||||
mean corpuscular volume | 6 | 11 | 14 | 98.7 | ||||||
mean corpuscular hemoglobin | 4 | 6 | 6 | 98.6 | ||||||
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 26 | 99.9 | |||||
mean corpuscular hemoglobin concentration | 26 | 99.9 | |||||
mean corpuscular volume | 14 | 98.7 | |||||
mean corpuscular volume | 14 | 98.7 | |||||
mean corpuscular hemoglobin | 6 | 98.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:96015 | 15122 | ||||||
Mouse | MGI:96016 | 110257 | ||||||
Rat | RGD:2782 | 25632 | ||||||
Dog | hemoglobin subunit alpha-like | 100855540 | ||||||
Cow | hemoglobin, alpha 1 | 100140149 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Dog | hemoglobin subunit alpha-like | |||||
Cow | hemoglobin, alpha 1 | |||||
Publication Statistics
PubMed Score 952.28
PubMed score by year
PubTator Score 7445.71
PubTator score by year
Related Publications
Text Mined References (555)
GeneRif Annotations (239)
Items per page:
0 of 0
PMID | Year | Title |
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