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Tbio
HAX1
HCLS1-associated protein X-1

Protein Summary
Description
Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328703
  • ENSP00000329002
  • ENSG00000143575
  • ENST00000447768
  • ENSP00000403848
  • ENST00000457918
  • ENSP00000411448
  • ENST00000483970
  • ENSP00000435088

Symbol
  • HS1BP1
  • SCN3
  • HS1BP1
  • HCLSBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.97
interacting protein
0.96
biological process
0.9
histone modification site profile
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.21   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 457   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.21   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 457   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
HIST1H2BL
Tdark
Novelty:  0.64500134
p_int:  0.999998324
p_ni:  0.000001639
p_wrong:  3.7e-8
Data Source:  BioPlex
HPCA
Tbio
Novelty:  0.01360155
p_int:  0.999995701
p_ni:  0.000002298
p_wrong:  0.000002001
Data Source:  BioPlex
SYN1
Tbio
Novelty:  0.00093242
p_int:  0.999993682
p_ni:  0.000006318
Data Source:  BioPlex
STX1B
Tbio
Novelty:  0.01171833
p_int:  0.999991765
p_ni:  0.000008235
Data Source:  BioPlex
DCLK1
Tchem
Family:  Kinase
Novelty:  0.0064994
p_int:  0.999989994
p_ni:  0.000010004
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
VSNL1
Tbio
Novelty:  0.01221371
p_int:  0.999988848
p_ni:  0.000011133
p_wrong:  1.9e-8
Data Source:  BioPlex
NAPB
Tdark
Novelty:  0.31464404
p_int:  0.999977884
p_ni:  0.000020755
p_wrong:  0.000001361
Data Source:  BioPlex
CAMK2A
Tchem
Family:  Kinase
Novelty:  0.00534906
p_int:  0.999962498
p_ni:  0.000037487
p_wrong:  1.5e-8
Data Source:  BioPlex
MAP2
Tbio
Novelty:  0.00068493
p_int:  0.99993843
p_ni:  0.000061537
p_wrong:  3.3e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
STX1A
Tbio
Novelty:  0.00087207
p_int:  0.999889082
p_ni:  0.000110917
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
4
4
91.2
C-reactive protein measurement
2
5
5
84.6
triglyceride measurement
2
2
2
76.7
smoking initiation
2
2
2
69.1
mean corpuscular hemoglobin
1
1
1
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
91.2
C-reactive protein measurement
5
84.6
triglyceride measurement
2
76.7
smoking initiation
2
69.1
mean corpuscular hemoglobin
1
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HCLS1 associated protein X-1
VGNC:9869
457347
Macaque
HCLS1 associated protein X-1
716495
Mouse
MGI:1346319
23897
Rat
RGD:727960
291202
Dog
HCLS1 associated protein X-1
480134
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HCLS1 associated protein X-1
Macaque
HCLS1 associated protein X-1
Mouse
Rat
Dog
HCLS1 associated protein X-1
Publication Statistics
PubMed Score 160.21
PubMed score by year
PubTator Score 124.40
PubTator score by year
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Related Publications
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PMID
Year
Title