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Tbio
HAVCR2
Hepatitis A virus cellular receptor 2

Protein Summary
Description
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307851
  • ENSP00000312002
  • ENSG00000135077

Symbol
  • TIM3
  • TIMD3
  • TIM3
  • CD366
  • KIM-3
  • TIMD3
  • Tim-3
  • TIMD-3
  • HAVcr-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.67
cell type or tissue
0.62
phenotype
0.58
protein domain
0.58
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 826.53   (req: < 5)
Gene RIFs: 240   (req: <= 3)
Antibodies: 885   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 826.53   (req: >= 5)
Gene RIFs: 240   (req: > 3)
Antibodies: 885   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (200)
PHLPP1
Tchem
Family:  Enzyme
Novelty:  0.00747239
p_int:  0.999999091
p_ni:  9.09e-7
Data Source:  BioPlex
ZDHHC5
Tbio
Family:  Enzyme
Novelty:  0.05205767
p_int:  0.999998269
p_ni:  0.000001731
Score:  0.181
Data Source:  BioPlex,STRINGDB
MAP3K21
Tbio
Family:  Kinase
Novelty:  0.14070877
p_int:  0.999997196
p_ni:  0.000002798
p_wrong:  6e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
DIP2B
Tdark
Novelty:  0.14642544
p_int:  0.999991687
p_ni:  0.000008313
Score:  0.181
Data Source:  BioPlex,STRINGDB
DENND6A
Tbio
Novelty:  4.5572617
p_int:  0.999953759
p_ni:  0.000046241
Data Source:  BioPlex
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.99993773
p_ni:  0.00006227
Data Source:  BioPlex
AGBL5
Tbio
Family:  Enzyme
Novelty:  0.05735805
p_int:  0.999878422
p_ni:  0.000121551
p_wrong:  2.7e-8
Data Source:  BioPlex
EXPH5
Tbio
Novelty:  0.07504682
p_int:  0.999860248
p_ni:  0.000139307
p_wrong:  4.45e-7
Data Source:  BioPlex
GOLGA7
Tbio
Novelty:  0.17108842
p_int:  0.999847129
p_ni:  0.000151751
p_wrong:  0.00000112
Data Source:  BioPlex
RIPK4
Tchem
Family:  Kinase
Novelty:  0.00818379
p_int:  0.999841692
p_ni:  0.000158308
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-2 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-2 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (47)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
T-cell immunoglobulin and mucin domain 1 measurement
1
2
2
95.3
total cholesterol measurement
3
3
5
89.3
blood protein measurement
1
1
1
87.8
low density lipoprotein cholesterol measurement
4
4
5
13.1
82.5
triglyceride measurement
2
1
3
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
T-cell immunoglobulin and mucin domain 1 measurement
2
95.3
total cholesterol measurement
5
89.3
blood protein measurement
1
87.8
low density lipoprotein cholesterol measurement
5
13.1
82.5
triglyceride measurement
3
70.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hepatitis A virus cellular receptor 2
VGNC:4031
462219
Mouse
MGI:2159682
171285
Rat
RGD:1305233
363578
Dog
hepatitis A virus cellular receptor 2
479318
Horse
hepatitis A virus cellular receptor 2
100071246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hepatitis A virus cellular receptor 2
Mouse
Rat
Dog
hepatitis A virus cellular receptor 2
Horse
hepatitis A virus cellular receptor 2
Publication Statistics
PubMed Score 826.53
PubMed score by year
PubTator Score 379.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title