Tbio HAUS7 HAUS augmin-like complex subunit 7

Protein Summary

Description

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Uniprot Accession IDs

• Q99871
• B4DUH6
• D3DWT9
• Q96HS8
• Q9NP54
• Q9UFH9

Gene Name

• HAUS7

Ensembl ID

• ENST00000370211
• ENSP00000359230
• ENSG00000213397

Symbol

• UCHL5IP
• UIP1
• UIP1
• UCHL5IP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
cellular component	0.82
interacting protein	0.79
cell type or tissue	0.66
tissue sample	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.03   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 251   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.03   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0