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Tbio
HAUS5
HAUS augmin-like complex subunit 5

Protein Summary
Description
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000203166
  • ENSP00000439056
  • ENSG00000249115
  • ENST00000587439
  • ENSP00000466661

Symbol
  • KIAA0841
  • dgt5
  • KIAA0841
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cellular component
0.74
co-expressed gene
0.69
microRNA
0.58
tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
HAUS7
Tbio
Novelty:  1.11657571
p_int:  0.99999854
p_ni:  0.00000146
Score:  0.968
Data Source:  BioPlex,STRINGDB
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.989541796
p_ni:  0.010458204
Data Source:  BioPlex
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.989403354
p_ni:  0.010596646
Data Source:  BioPlex
CNKSR1
Tchem
Family:  Enzyme
Novelty:  0.06710697
p_int:  0.983351501
p_ni:  0.016648499
Score:  0.188
Data Source:  BioPlex,STRINGDB
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.963035106
p_ni:  0.036964894
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.941207981
p_ni:  0.058792019
Data Source:  BioPlex
USP28
Tchem
Family:  Enzyme
Novelty:  0.02432294
p_int:  0.928937916
p_ni:  0.071062084
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.919858596
p_ni:  0.080141404
Score:  0.166
Data Source:  BioPlex,STRINGDB
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.891538664
p_ni:  0.108461336
Data Source:  BioPlex
RFXANK
Tbio
Novelty:  0.00355465
p_int:  0.875521931
p_ni:  0.124478069
Score:  0.26
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

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Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
5
84.5
serum alanine aminotransferase measurement
2
1
1
6.9
70.1
high density lipoprotein cholesterol measurement
5
1
5
63.9
phospholipids:total lipids ratio
1
1
1
63.9
educational attainment
1
2
2
62.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
84.5
serum alanine aminotransferase measurement
1
6.9
70.1
high density lipoprotein cholesterol measurement
5
63.9
phospholipids:total lipids ratio
1
63.9
educational attainment
2
62.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 5
VGNC:2411
455956
Macaque
HAUS augmin like complex subunit 5
718781
Mouse
MGI:1919159
71909
Rat
RGD:2318093
100362495
Dog
HAUS augmin like complex subunit 5
VGNC:41605
476481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 5
Macaque
HAUS augmin like complex subunit 5
Mouse
Rat
Dog
HAUS augmin like complex subunit 5
Publication Statistics
PubMed Score 2.54
PubMed score by year
PubTator Score 1.14
PubTator score by year
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Related Publications
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0 of 0
PMID
Text