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Tbio
HAUS4
HAUS augmin-like complex subunit 4

Protein Summary
Description
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000206474
  • ENSP00000206474
  • ENSG00000092036
  • ENST00000342454
  • ENSP00000342776
  • ENST00000347758
  • ENSP00000343473
  • ENST00000490506
  • ENSP00000452260
  • ENST00000541587
  • ENSP00000441026
  • ENST00000555367
  • ENSP00000452239
  • ENST00000555986
  • ENSP00000451018

Symbol
  • C14orf94
  • C14orf94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
kinase perturbation
0.81
transcription factor
0.68
transcription factor binding site profile
0.63
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
HAUS7
Tbio
Novelty:  1.11657571
p_int:  0.999999964
p_ni:  3.6e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
CCDC59
Tbio
Novelty:  0.05894885
p_int:  0.999999222
p_ni:  7.77e-7
Data Source:  BioPlex
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999967885
p_ni:  0.000032115
Data Source:  BioPlex
PCM1
Tbio
Novelty:  0.02901589
p_int:  0.999915824
p_ni:  0.000083818
p_wrong:  3.57e-7
Score:  0.901
Data Source:  BioPlex,STRINGDB
BSPRY
Tdark
Novelty:  0.38200913
p_int:  0.999843311
p_ni:  0.000156689
Data Source:  BioPlex
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.999598684
p_ni:  0.000401293
p_wrong:  2.4e-8
Data Source:  BioPlex
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
p_int:  0.999199404
p_ni:  0.000800596
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.997571868
p_ni:  0.002428115
p_wrong:  1.7e-8
Data Source:  BioPlex
EFHC1
Tbio
Novelty:  0.01722469
p_int:  0.996131059
p_ni:  0.003868941
Score:  0.214
Data Source:  BioPlex,STRINGDB
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.995751858
p_ni:  0.004239477
p_wrong:  0.000008665
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
6
10
99.4
reticulocyte count
6
3
6
97
reticulocyte measurement
3
2
3
94.7
self reported educational attainment
4
4
3
5.7
91
mathematical ability
4
3
4
86.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
99.4
reticulocyte count
6
97
reticulocyte measurement
3
94.7
self reported educational attainment
3
5.7
91
mathematical ability
4
86.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 4
VGNC:12694
452790
Mouse
MGI:1261794
219072
Rat
RGD:1305288
305882
Horse
HAUS augmin like complex subunit 4
100052680
Cow
HAUS augmin like complex subunit 4
614307
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 4
Mouse
Rat
Horse
HAUS augmin like complex subunit 4
Cow
HAUS augmin like complex subunit 4
Publication Statistics
PubMed Score 1.27
PubMed score by year
PubTator Score 0.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title