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Tbio
HAUS3
HAUS augmin-like complex subunit 3

Protein Summary
Description
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243706
  • ENSP00000243706
  • ENSG00000214367
  • ENST00000443786
  • ENSP00000392903
  • ENST00000506763
  • ENSP00000427350

Symbol
  • C4orf15
  • IT1
  • dgt3
  • C4orf15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
interacting protein
0.73
tissue
0.66
histone modification site profile
0.64
microRNA
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
HAUS7
Tbio
Novelty:  1.11657571
p_int:  1
Score:  0.954
Data Source:  BioPlex,STRINGDB
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999940537
p_ni:  0.000059463
Data Source:  BioPlex
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.999873037
p_ni:  0.000125029
p_wrong:  0.000001934
Data Source:  BioPlex
COG3
Tbio
Novelty:  0.02746711
p_int:  0.996097101
p_ni:  0.003902896
p_wrong:  3e-9
Score:  0.395
Data Source:  BioPlex,STRINGDB
BEX5
Tdark
Novelty:  0.2964824
p_int:  0.991087027
p_ni:  0.008905507
p_wrong:  0.000007466
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.968248806
p_ni:  0.021725975
p_wrong:  0.01002522
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.947670331
p_ni:  0.046206395
p_wrong:  0.006123274
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.912303606
p_ni:  0.046521553
p_wrong:  0.041174841
Data Source:  BioPlex
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.82758249
p_ni:  0.009408246
p_wrong:  0.163009264
Data Source:  BioPlex
HAUS6
Tbio
Novelty:  0.11011519
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
2
2
79.2
body weight
2
2
2
63.4
high density lipoprotein cholesterol measurement
2
2
2
32.2
body height
1
1
1
31.7
body mass index
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
79.2
body weight
2
63.4
high density lipoprotein cholesterol measurement
2
32.2
body height
1
31.7
body mass index
1
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 3
VGNC:609
104005956
Macaque
HAUS augmin like complex subunit 3
106998230
Mouse
MGI:2387633
231123
Rat
RGD:1591723
680477
Dog
HAUS augmin like complex subunit 3
VGNC:41604
100688432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 3
Macaque
HAUS augmin like complex subunit 3
Mouse
Rat
Dog
HAUS augmin like complex subunit 3
Publication Statistics
PubMed Score 618.61
PubMed score by year
PubTator Score 71.43
PubTator score by year
Related Publications
No publications found