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Tbio
HAUS2
HAUS augmin-like complex subunit 2

Protein Summary
Description
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260372
  • ENSP00000260372
  • ENSG00000137814
  • ENST00000568876
  • ENSP00000456578

Symbol
  • C15orf25
  • CEP27
  • CEP27
  • C15orf25
  • HsT17025
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.88
transcription factor perturbation
0.74
cellular component
0.69
transcription factor binding site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.85   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.85   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
HAUS7
Tbio
Novelty:  1.11657571
p_int:  1
Score:  0.994
Data Source:  BioPlex,STRINGDB
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.999989455
p_ni:  0.000010466
p_wrong:  7.9e-8
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.985753165
p_ni:  0.001298091
p_wrong:  0.012948743
Score:  0.188
Data Source:  BioPlex,STRINGDB
HAUS8
Tbio
Novelty:  0.46177875
Score:  0.998
Data Source:  STRINGDB
HAUS6
Tbio
Novelty:  0.11011519
Score:  0.998
Data Source:  STRINGDB
HAUS5
Tbio
Novelty:  0.99720546
Score:  0.997
Data Source:  STRINGDB
HAUS4
Tbio
Novelty:  0.91427982
Score:  0.997
Data Source:  STRINGDB
HAUS1
Tbio
Novelty:  0.11356375
Score:  0.996
Data Source:  STRINGDB
HAUS3
Tbio
Novelty:  0.00398858
Score:  0.994
Data Source:  STRINGDB
CEP192
Tbio
Novelty:  0.05738998
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
67.9
hemoglobin measurement
1
1
1
30.2
2
1
1
1.1
26.1
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
67.9
hemoglobin measurement
1
30.2
1
1.1
26.1
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 2
VGNC:3547
741061
Macaque
HAUS augmin like complex subunit 2
708325
Mouse
MGI:1913546
66296
Dog
HAUS augmin like complex subunit 2
VGNC:41603
478270
Cow
HAUS augmin like complex subunit 2
VGNC:29758
508698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 2
Macaque
HAUS augmin like complex subunit 2
Mouse
Dog
HAUS augmin like complex subunit 2
Cow
HAUS augmin like complex subunit 2
Publication Statistics
PubMed Score 1.85
PubMed score by year
PubTator Score 0.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title