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Tbio
HAUS1
HAUS augmin-like complex subunit 1

Protein Summary
Description
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282058
  • ENSP00000282058
  • ENSG00000152240

Symbol
  • CCDC5
  • HEIC
  • HEIC
  • CCDC5
  • HEI-C
  • HsT1461
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
interacting protein
0.76
cell type or tissue
0.73
virus perturbation
0.68
cellular component
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
HAUS7
Tbio
Novelty:  1.11657571
p_int:  0.999999967
p_ni:  3.2e-8
p_wrong:  1e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
SKA2
Tbio
Novelty:  0.03605487
p_int:  0.999987847
p_ni:  0.000012147
p_wrong:  6e-9
Score:  0.292
Data Source:  BioPlex,STRINGDB
CCDC59
Tbio
Novelty:  0.05894885
p_int:  0.999970151
p_ni:  0.000029844
p_wrong:  5e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999964736
p_ni:  0.000035264
Data Source:  BioPlex
VTI1A
Tbio
Novelty:  0.04616617
p_int:  0.999800125
p_ni:  0.000196275
p_wrong:  0.000003599
Score:  0.656
Data Source:  BioPlex,STRINGDB
PCM1
Tbio
Novelty:  0.02901589
p_int:  0.99962214
p_ni:  0.000377858
p_wrong:  2e-9
Score:  0.9
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999584281
p_ni:  0.000415636
p_wrong:  8.3e-8
Data Source:  BioPlex
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999486098
p_ni:  0.000513899
p_wrong:  3e-9
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.998703684
p_ni:  0.001296258
p_wrong:  5.9e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
TPTE2
Tbio
Family:  Enzyme
Novelty:  0.04710658
p_int:  0.998509666
p_ni:  0.001490334
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

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1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
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GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
4
4
98.9
reticulocyte measurement
2
2
2
89.6
mean corpuscular hemoglobin concentration
2
2
2
89.4
red blood cell density measurement
1
1
1
85.5
reticulocyte count
2
1
2
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
98.9
reticulocyte measurement
2
89.6
mean corpuscular hemoglobin concentration
2
89.4
red blood cell density measurement
1
85.5
reticulocyte count
2
82.5
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IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 1
VGNC:5172
739317
Macaque
HAUS augmin like complex subunit 1
695871
Mouse
MGI:2385076
225745
Rat
108348136
Dog
HAUS augmin like complex subunit 1
VGNC:41602
480148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 1
Macaque
HAUS augmin like complex subunit 1
Mouse
Rat
Dog
HAUS augmin like complex subunit 1
Publication Statistics
PubMed Score 8.29
PubMed score by year
PubTator Score 13.33
PubTator score by year
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Related Publications
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PMID
Text