HAS2
Hyaluronan synthase 2
Protein Summary
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extrac ...more
- ENST00000303924
- ENSP00000306991
- ENSG00000170961
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.98 | ||
PubMedID | 0.97 | ||
pathway | 0.92 | ||
biological process | 0.85 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 420.33 (req: < 5)
Gene RIFs: 79 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 420.33 (req: >= 5)
Gene RIFs: 79 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (77)
Nearest Tclin Targets
Pathways (6)
Reactome (5)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glycosaminoglycan metabolism | ||||
Reactome | Hyaluronan biosynthesis and export | ||||
Reactome | Hyaluronan metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glycosaminoglycan metabolism | ||||
Hyaluronan biosynthesis and export | ||||
Hyaluronan metabolism | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (2)
Components (2)
Processes (24)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hematocrit | 1 | 1 | 1 | 44.2 | |||||
pulse pressure measurement | 1 | 1 | 0 | 4.5 | 33.1 | ||||
self reported educational attainment | 1 | 1 | 0 | 4.5 | 33.1 | ||||
balding measurement | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hematocrit | 1 | 44.2 | |||||
pulse pressure measurement | 0 | 4.5 | 33.1 | ||||
self reported educational attainment | 0 | 4.5 | 33.1 | ||||
balding measurement | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:107821 | 15117 | ||||||
Rat | RGD:2781 | 25694 | ||||||
Dog | hyaluronan synthase 2 | VGNC:41600 | 482032 | |||||
Horse | hyaluronan synthase 2 | VGNC:18696 | 100009708 | |||||
Cow | hyaluronan synthase 2 | VGNC:29755 | 281220 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | hyaluronan synthase 2 | |||||
Horse | hyaluronan synthase 2 | |||||
Cow | hyaluronan synthase 2 | |||||
Publication Statistics
PubMed Score 420.33
PubMed score by year
PubTator Score 403.20
PubTator score by year
Related Publications
Text Mined References (88)
GeneRif Annotations (79)
Items per page:
0 of 0
PMID | Year | Title |
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