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Tbio
HAS2
Hyaluronan synthase 2

Protein Summary
Description
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extrac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303924
  • ENSP00000306991
  • ENSG00000170961
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
PubMedID
0.97
pathway
0.92
biological process
0.85
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.33   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.33   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
HYAL1
Tbio
Family:  Enzyme
Novelty:  0.00756819
Score:  0.817
Data Source:  STRINGDB
HYAL2
Tbio
Family:  Enzyme
Novelty:  0.00740331
Score:  0.815
Data Source:  STRINGDB
HMMR
Tchem
Novelty:  0.0039196
Score:  0.804
Data Source:  STRINGDB
CD44
Tbio
Novelty:  0.00011321
Score:  0.8
Data Source:  STRINGDB
SPAM1
Tbio
Family:  Enzyme
Novelty:  0.0041597
Score:  0.772
Data Source:  STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.747
Data Source:  STRINGDB
TNFAIP6
Tbio
Novelty:  0.0046811
Score:  0.725
Data Source:  STRINGDB
AREG
Tchem
Novelty:  0.0017631
Score:  0.674
Data Source:  STRINGDB
HABP2
Tbio
Family:  Enzyme
Novelty:  0.00332789
Score:  0.665
Data Source:  STRINGDB
PTX3
Tbio
Novelty:  0.00153752
Score:  0.641
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan biosynthesis and export
Reactome
Hyaluronan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Hyaluronan biosynthesis and export
Hyaluronan metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
44.2
pulse pressure measurement
1
1
0
4.5
33.1
self reported educational attainment
1
1
0
4.5
33.1
balding measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
44.2
pulse pressure measurement
0
4.5
33.1
self reported educational attainment
0
4.5
33.1
balding measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107821
15117
Rat
RGD:2781
25694
Dog
hyaluronan synthase 2
VGNC:41600
482032
Horse
hyaluronan synthase 2
VGNC:18696
100009708
Cow
hyaluronan synthase 2
VGNC:29755
281220
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
hyaluronan synthase 2
Horse
hyaluronan synthase 2
Cow
hyaluronan synthase 2
Publication Statistics
PubMed Score 420.33
PubMed score by year
PubTator Score 403.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title