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Tbio
HARS2
Probable histidine--tRNA ligase, mitochondrial

Protein Summary
Description
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230771
  • ENSP00000230771
  • ENSG00000112855
  • ENST00000508522
  • ENSP00000423616
  • ENST00000642231
  • ENSP00000494569
  • ENST00000645749
  • ENSP00000494296

Symbol
  • HARSL
  • HARSR
  • HO3
  • HO3
  • HARSL
  • HARSR
  • HisRS
  • PRLTS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.91
disease perturbation
0.9
interacting protein
0.83
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
HARS
Tchem
Family:  Enzyme
Novelty:  0.01271582
p_int:  0.999805545
p_ni:  0.000194455
Score:  0.84
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.99942868
p_ni:  0.00057132
Score:  0.332
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.986216156
p_ni:  0.013783844
Score:  0.273
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.976854993
p_ni:  0.023145002
p_wrong:  5e-9
Score:  0.258
Data Source:  BioPlex,STRINGDB
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.975541942
p_ni:  0.024458055
p_wrong:  3e-9
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.973122785
p_ni:  0.02687709
p_wrong:  1.25e-7
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.973061057
p_ni:  0.026938894
p_wrong:  4.9e-8
Data Source:  BioPlex
CD79A
Tbio
Novelty:  0.00118942
p_int:  0.97114092
p_ni:  0.028859079
p_wrong:  1e-9
Data Source:  BioPlex
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.959975293
p_ni:  0.040024698
p_wrong:  9e-9
Score:  0.162
Data Source:  BioPlex,STRINGDB
MRPL21
Tdark
Novelty:  0.56552559
p_int:  0.958472226
p_ni:  0.041527773
Score:  0.31
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
WormBase
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
3
1
5.9
56.4
4
2
1
1.1
46
self reported educational attainment
2
2
2
45.2
household income
1
1
1
24.5
cognitive function measurement
3
1
3
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
5.9
56.4
1
1.1
46
self reported educational attainment
2
45.2
household income
1
24.5
cognitive function measurement
3
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histidyl-tRNA synthetase 2, mitochondrial
VGNC:4029
462123
Macaque
histidyl-tRNA synthetase 2, mitochondrial
697009
Mouse
MGI:1918041
70791
Rat
RGD:1308426
307491
Dog
histidyl-tRNA synthetase 2, mitochondrial
VGNC:41598
478035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histidyl-tRNA synthetase 2, mitochondrial
Macaque
histidyl-tRNA synthetase 2, mitochondrial
Mouse
Rat
Dog
histidyl-tRNA synthetase 2, mitochondrial
Publication Statistics
PubMed Score 416.59
PubMed score by year
PubTator Score 66.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title