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Tbio
HAPLN3
Hyaluronan and proteoglycan link protein 3

Protein Summary
Description
May function in hyaluronic acid binding. This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359595
  • ENSP00000352606
  • ENSG00000140511

Symbol
  • EXLD1
  • EXLD1
  • HsT19883
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.71
tissue sample
0.63
cell line
0.51
histone modification site profile
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
A2M
Tbio
Novelty:  0.00070446
p_int:  0.999987194
p_ni:  0.000012798
p_wrong:  8e-9
Score:  0.24
Data Source:  BioPlex,STRINGDB
CHAC2
Tbio
Family:  Enzyme
Novelty:  0.14706039
p_int:  0.999980243
p_ni:  0.00001975
p_wrong:  7e-9
Score:  0.297
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.998743026
p_ni:  0.001256949
p_wrong:  2.4e-8
Data Source:  BioPlex
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.998106593
p_ni:  0.0018934
p_wrong:  7e-9
Data Source:  BioPlex
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.997919746
p_ni:  0.002080239
p_wrong:  1.5e-8
Data Source:  BioPlex
FUT3
Tbio
Family:  Enzyme
Novelty:  0.0059835
p_int:  0.995969693
p_ni:  0.001362138
p_wrong:  0.002668169
Score:  0.179
Data Source:  BioPlex,STRINGDB
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.985536662
p_ni:  0.013093975
p_wrong:  0.001369363
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.985484672
p_ni:  0.013344285
p_wrong:  0.001171043
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.941495146
p_ni:  0.058504854
Data Source:  BioPlex
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
p_int:  0.935911023
p_ni:  0.009692549
p_wrong:  0.054396428
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
10
12
97.8
appendicular lean mass
5
3
6
94.5
BMI-adjusted hip circumference
3
26
27
94.4
body fat distribution
3
2
12
92.9
BMI-adjusted waist circumference
5
10
15
87.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
12
97.8
appendicular lean mass
6
94.5
BMI-adjusted hip circumference
27
94.4
body fat distribution
12
92.9
BMI-adjusted waist circumference
15
87.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyaluronan and proteoglycan link protein 3
VGNC:3548
453630
Macaque
hyaluronan and proteoglycan link protein 3
698880
Mouse
MGI:1914916
67666
Rat
RGD:1308098
308773
Dog
hyaluronan and proteoglycan link protein 3
VGNC:41594
609165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyaluronan and proteoglycan link protein 3
Macaque
hyaluronan and proteoglycan link protein 3
Mouse
Rat
Dog
hyaluronan and proteoglycan link protein 3
Publication Statistics
PubMed Score 5.78
PubMed score by year
PubTator Score 2.65
PubTator score by year
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Related Publications
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PMID
Year
Title