You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HAPLN2
Hyaluronan and proteoglycan link protein 2

Protein Summary
Description
Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255039
  • ENSP00000255039
  • ENSG00000132702

Symbol
  • BRAL1
  • BRAL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.5
kinase perturbation
0.48
metabolite
0.45
chemical
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.74   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.74   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
GLDN
Tbio
Novelty:  0.01859604
Score:  0.724
Data Source:  STRINGDB
GFAP
Tbio
Novelty:  0.00020932
Score:  0.671
Data Source:  STRINGDB
ARHGEF11
Tbio
Novelty:  0.01942359
Score:  0.626
Data Source:  STRINGDB
WDR27
Tdark
Novelty:  1.32523881
Score:  0.619
Data Source:  STRINGDB
PTPRZ1
Tchem
Family:  Enzyme
Novelty:  0.00518159
Score:  0.617
Data Source:  STRINGDB
TMEM235
Tdark
Novelty:  0.92307692
Score:  0.608
Data Source:  STRINGDB
PSMB1
Tclin
Family:  Enzyme
Novelty:  0.0255917
Score:  0.597
Data Source:  STRINGDB
PDE10A
Tclin
Family:  Enzyme
Novelty:  0.00318215
Score:  0.597
Data Source:  STRINGDB
CNTN2
Tbio
Novelty:  0.00213251
Score:  0.588
Data Source:  STRINGDB
NFASC
Tbio
Novelty:  0.00545331
Score:  0.581
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
1
1
1
46.5
platelet count
1
1
1
36.9
platelet crit
1
1
1
13.6
BMI-adjusted waist circumference
1
1
1
12.3
body height
1
1
1
12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
1
46.5
platelet count
1
36.9
platelet crit
1
13.6
BMI-adjusted waist circumference
1
12.3
body height
1
12
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2137300
73940
Rat
RGD:621854
64057
Dog
hyaluronan and proteoglycan link protein 2
VGNC:53491
490411
Horse
hyaluronan and proteoglycan link protein 2
VGNC:18692
100058030
Cow
hyaluronan and proteoglycan link protein 2
VGNC:29750
514791
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
hyaluronan and proteoglycan link protein 2
Horse
hyaluronan and proteoglycan link protein 2
Cow
hyaluronan and proteoglycan link protein 2
Publication Statistics
PubMed Score 8.74
PubMed score by year
PubTator Score 4.96
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title