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Tchem
HAO2
Hydroxyacid oxidase 2

Protein Summary
Description
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids. This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325945
  • ENSP00000316339
  • ENSG00000116882
  • ENST00000361035
  • ENSP00000354314
  • ENST00000622548
  • ENSP00000483507

Symbol
  • HAOX2
  • GIG16
  • HAOX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cellular component
0.74
gene perturbation
0.68
cell type or tissue
0.67
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (142)
PPFIBP1
Tbio
Novelty:  0.09685089
p_int:  0.999999679
p_ni:  3.19e-7
p_wrong:  2e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
SMG6
Tbio
Family:  Enzyme
Novelty:  0.0217417
p_int:  0.999993395
p_ni:  0.000006598
p_wrong:  7e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.999959923
p_ni:  0.000040077
Score:  0.176
Data Source:  BioPlex,STRINGDB
RBPMS
Tbio
Novelty:  0.01727259
p_int:  0.999887144
p_ni:  0.000112837
p_wrong:  1.9e-8
Score:  0.546
Data Source:  BioPlex,STRINGDB
RBPMS2
Tbio
Novelty:  0.14005113
p_int:  0.999862809
p_ni:  0.000137186
p_wrong:  6e-9
Score:  0.527
Data Source:  BioPlex,STRINGDB
PM20D2
Tdark
Family:  Enzyme
Novelty:  0.63491472
p_int:  0.999430132
p_ni:  0.000569868
Score:  0.175
Data Source:  BioPlex,STRINGDB
BCOR
Tbio
Novelty:  0.05718292
p_int:  0.998665634
p_ni:  0.001334366
Data Source:  BioPlex
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.995217731
p_ni:  0.004782269
Data Source:  BioPlex
TNIP1
Tbio
Novelty:  0.0147254
p_int:  0.994058647
p_ni:  0.005941351
p_wrong:  2e-9
Data Source:  BioPlex
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.991631686
p_ni:  0.008368313
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Reactome
Peroxisomal protein import
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Peroxisomal protein import
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
6
6
90.8
waist circumference
1
5
5
83.7
waist-hip ratio
2
2
3
72.2
BMI-adjusted waist-hip ratio
2
2
3
69.6
folding of antihelix
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
90.8
waist circumference
5
83.7
waist-hip ratio
3
72.2
BMI-adjusted waist-hip ratio
3
69.6
folding of antihelix
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxyacid oxidase 2
VGNC:9035
457163
Macaque
hydroxyacid oxidase 2
712615
Mouse
MGI:96012
56185
Rat
RGD:70972
84029
Dog
hydroxyacid oxidase 2
VGNC:41591
475814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxyacid oxidase 2
Macaque
hydroxyacid oxidase 2
Mouse
Rat
Dog
hydroxyacid oxidase 2
Publication Statistics
PubMed Score 31.33
PubMed score by year
PubTator Score 77.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title