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Tbio
HAND2
Heart- and neural crest derivatives-expressed protein 2

Protein Summary
Description
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359562
  • ENSP00000352565
  • ENSG00000164107

Symbol
  • BHLHA26
  • DHAND
  • Hed
  • dHand
  • DHAND2
  • Thing2
  • bHLHa26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.95
gene perturbation
0.91
phenotype
0.68
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.9   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.9   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
58.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
58.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heart and neural crest derivatives expressed 2
741581
Mouse
MGI:103580
15111
Dog
heart and neural crest derivatives expressed 2 [Source:HGNC Symbol;Acc:HGNC:4808]
Horse
heart and neural crest derivatives expressed 2
VGNC:18688
100066124
Cow
heart and neural crest derivatives expressed 2
VGNC:29747
781874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heart and neural crest derivatives expressed 2
Mouse
Dog
heart and neural crest derivatives expressed 2 [Source:HGNC Symbol;Acc:HGNC:4808]
Horse
heart and neural crest derivatives expressed 2
Cow
heart and neural crest derivatives expressed 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P61296-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional regulation by RUNX2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Transcriptional regulation by RUNX2
Gene Ontology Terms (51)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (143)
1 – 10 of 143
TCF3
Tbio
Family: TF
Novelty: 0.00112675
p_int: 0.999999907
p_ni: 9.3e-8
Score: 0.644
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
p_int: 0.99999969
p_ni: 3.11e-7
Score: 0.514
Data Source: BioPlex,STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00381424
p_int: 0.999999299
p_ni: 7.01e-7
Score: 0.49
Data Source: BioPlex,STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.992
Data Source: STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
Score: 0.98
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.971
Data Source: STRINGDB
HAND1
Tbio
Family: TF
Novelty: 0.00556481
Score: 0.946
Data Source: STRINGDB
NFATC1
Tbio
Family: TF
Novelty: 0.00130337
Score: 0.923
Data Source: STRINGDB
ADSS
Tchem
Family: Enzyme
Novelty: 0.0126472
Score: 0.9
Data Source: STRINGDB
ELSPBP1
Tbio
Novelty: 0.0179246
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  221.90

PubMed score by year
PubTator Score  96.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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