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Histidine ammonia-lyase

Protein Summary
Description
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261208
  • ENSP00000261208
  • ENSG00000084110
  • ENST00000538703
  • ENSP00000440861
  • ENST00000541929
  • ENSP00000446364

Symbol
  • HIS
  • HIS
  • HSTD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.73
gene perturbation
0.68
kinase perturbation
0.6
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.48   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.48   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
PLEKHA3
Tbio
Novelty:  0.06598909
p_int:  0.999999978
p_wrong:  2.1e-8
Score:  0.325
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999978097
p_ni:  0.000021903
Score:  0.152
Data Source:  BioPlex,STRINGDB
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.999320799
p_ni:  0.000679201
Data Source:  BioPlex
DPPA4
Tbio
Novelty:  0.05764302
p_int:  0.997934813
p_ni:  0.002065187
Data Source:  BioPlex
UBAC2
Tbio
Novelty:  0.13384376
p_int:  0.996894898
p_ni:  0.003105102
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.995804506
p_ni:  0.004195486
p_wrong:  7e-9
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.993988949
p_ni:  0.006011051
Data Source:  BioPlex
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
p_int:  0.98914512
p_ni:  0.010854879
Data Source:  BioPlex
TXNDC16
Tdark
Novelty:  0.25365147
p_int:  0.988991094
p_ni:  0.011008905
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.987395174
p_ni:  0.012604826
Data Source:  BioPlex
Pathways (10)
Histidine catabolism (R-HSA-70921)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Histidine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Histidine catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
6
7
10
99.1
vitamin D deficiency
1
1
1
80.9
blood metabolite measurement
1
2
2
74.6
amino acid measurement
1
2
2
74.6
protein measurement
1
2
2
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
10
99.1
vitamin D deficiency
1
80.9
blood metabolite measurement
2
74.6
amino acid measurement
2
74.6
protein measurement
2
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histidine ammonia-lyase
VGNC:5413
452144
Macaque
histidine ammonia-lyase
712963
Mouse
MGI:96010
15109
Rat
RGD:68363
29301
Dog
histidine ammonia-lyase
VGNC:41587
475433
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histidine ammonia-lyase
Macaque
histidine ammonia-lyase
Mouse
Rat
Dog
histidine ammonia-lyase
Publication Statistics
PubMed Score 68.48
PubMed score by year
PubTator Score 312.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title