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Tbio
HADHB
Trifunctional enzyme subunit beta, mitochondrial

Protein Summary
Description
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317799
  • ENSP00000325136
  • ENSG00000138029
  • ENST00000545822
  • ENSP00000442665

Symbol
  • ECHB
  • MTPB
  • MSTP029
  • TP-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
co-expressed gene
0.99
disease perturbation
0.99
molecular function
0.98
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.63   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.63   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
GPC1
Tbio
Novelty:  0.00293087
p_int:  0.999988623
p_ni:  0.000011377
Score:  0.173
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.996051495
p_ni:  0.003948505
Data Source:  BioPlex
RELL2
Tbio
Novelty:  0.59290726
p_int:  0.991286481
p_ni:  0.008713519
Score:  0.514
Data Source:  BioPlex,STRINGDB
CD44
Tbio
Novelty:  0.00011321
p_int:  0.990772667
p_ni:  0.009227333
Score:  0.294
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.980467176
p_ni:  0.019532824
Data Source:  BioPlex
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.978996727
p_ni:  0.021003273
Data Source:  BioPlex
CDH8
Tbio
Novelty:  0.04055999
p_int:  0.970162548
p_ni:  0.029837452
Score:  0.473
Data Source:  BioPlex,STRINGDB
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.958301207
p_ni:  0.041698792
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
C17orf80
Tbio
Novelty:  0.15267004
p_int:  0.942654139
p_ni:  0.057345861
Score:  0.622
Data Source:  BioPlex,STRINGDB
IL7R
Tbio
Novelty:  0.00107223
p_int:  0.903166905
p_ni:  0.096833094
Data Source:  BioPlex
Pathways (36)
Acyl chain remodeling of CL (R-HSA-1482798)

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Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of CL
Reactome
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Reactome
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Reactome
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Reactome
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of CL
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
21.5
IGF-1 measurement
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
21.5
IGF-1 measurement
1
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
VGNC:48985
459080
Macaque
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
698025
Mouse
MGI:2136381
231086
Rat
RGD:620513
171155
Dog
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
607926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Macaque
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Mouse
Rat
Dog
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Publication Statistics
PubMed Score 106.63
PubMed score by year
PubTator Score 91.10
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title