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Tbio
HADHA
Trifunctional enzyme subunit alpha, mitochondrial

Protein Summary
Description
Bifunctional subunit. This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380649
  • ENSP00000370023
  • ENSG00000084754
  • ENST00000646483
  • ENSP00000496185

Symbol
  • HADH
  • GBP
  • ECHA
  • HADH
  • LCEH
  • MTPA
  • LCHAD
  • TP-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
molecular function
0.98
disease perturbation
0.96
hub protein
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.26   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.26   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
GPC1
Tbio
Novelty:  0.00293087
p_int:  0.999999993
p_ni:  6e-9
Data Source:  BioPlex
Q9HDB5
Tbio
Novelty:  0.00999084
p_int:  0.999999947
p_ni:  5.3e-8
Data Source:  BioPlex
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.999999794
p_ni:  6.4e-8
p_wrong:  1.43e-7
Data Source:  BioPlex
SDC4
Tbio
Novelty:  0.00319073
p_int:  0.999998811
p_ni:  1.11e-7
p_wrong:  0.000001078
Data Source:  BioPlex
TGFBR3
Tbio
Novelty:  0.0077307
p_int:  0.999997483
p_ni:  0.000002517
Data Source:  BioPlex
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.999988857
p_ni:  0.000011143
Data Source:  BioPlex
AGRN
Tbio
Novelty:  0.00156441
p_int:  0.999979003
p_ni:  0.000020985
p_wrong:  1.2e-8
Data Source:  BioPlex
GPC2
Tbio
Novelty:  0.02182363
p_int:  0.999973997
p_ni:  3.43e-7
p_wrong:  0.000025659
Data Source:  BioPlex
C17orf80
Tbio
Novelty:  0.15267004
p_int:  0.999973003
p_ni:  0.000026982
p_wrong:  1.5e-8
Data Source:  BioPlex
OSBPL8
Tbio
Novelty:  0.06812531
p_int:  0.999759809
p_ni:  0.000240191
Data Source:  BioPlex
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (44)
Acyl chain remodeling of CL (R-HSA-1482798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of CL
Reactome
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Reactome
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Reactome
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Reactome
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of CL
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of myristoyl-CoA to lauroyl-CoA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
13.5
IGF-1 measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
13.5
IGF-1 measurement
1
3.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
VGNC:48984
459079
Macaque
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
695975
Mouse
MGI:2135593
97212
Rat
RGD:620512
170670
Dog
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
VGNC:49107
100856745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Macaque
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Mouse
Rat
Dog
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Publication Statistics
PubMed Score 382.26
PubMed score by year
PubTator Score 220.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title