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Tbio
H6PD
GDH/6PGL endoplasmic bifunctional protein

Protein Summary
Description
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377403
  • ENSP00000366620
  • ENSG00000049239

Symbol
  • GDH
  • GDH
  • G6PDH
  • CORTRD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.88
disease perturbation
0.87
transcription factor binding site profile
0.82
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.26   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.26   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (371)
FBXO6
Tbio
Novelty:  0.02173918
p_int:  0.999999946
p_ni:  5.1e-8
p_wrong:  3e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
ANTXR1
Tbio
Novelty:  0.00508081
p_int:  0.99996046
p_ni:  0.000039515
p_wrong:  2.5e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.996764445
p_ni:  0.002816923
p_wrong:  0.000418632
Score:  0.319
Data Source:  BioPlex,STRINGDB
CCL3L1
Tbio
Novelty:  0.01124082
p_int:  0.995602035
p_ni:  0.004397519
p_wrong:  4.46e-7
Data Source:  BioPlex
PGD
Tchem
Family:  Enzyme
Novelty:  0.00576529
Score:  0.998
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.991
Data Source:  STRINGDB
IDNK
Tbio
Family:  Kinase
Novelty:  0.07579524
Score:  0.974
Data Source:  STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.967
Data Source:  STRINGDB
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.966
Data Source:  STRINGDB
PGM1
Tbio
Family:  Enzyme
Novelty:  0.00163947
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Carbon metabolism
KEGG
Metabolic pathways
KEGG
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
Carbon metabolism
Metabolic pathways
Pentose phosphate pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
11
12
93.7
waist-hip ratio
3
10
11
90.6
BMI-adjusted hip circumference
2
11
11
88.3
eosinophil percentage of leukocytes
2
3
3
87.3
monocyte percentage of leukocytes
2
1
2
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
93.7
waist-hip ratio
11
90.6
BMI-adjusted hip circumference
11
88.3
eosinophil percentage of leukocytes
3
87.3
monocyte percentage of leukocytes
2
77.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
VGNC:9873
100610187
Macaque
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
710107
Mouse
MGI:2140356
100198
Rat
RGD:1306562
298655
Dog
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
VGNC:41579
489642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
Macaque
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
Mouse
Rat
Dog
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
Publication Statistics
PubMed Score 248.26
PubMed score by year
PubTator Score 473.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title