Protein Summary
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, ...more
- ENST00000254810
- ENSP00000254810
- ENSG00000132475
- ENST00000366813
- ENSP00000355778
- ENSG00000163041
- ENST00000366815
- ENSP00000355780
- ENST00000366816
- ENSP00000355781
- ENST00000586607
- ENSP00000466020
- ENST00000587560
- ENSP00000468714
- ENST00000589599
- ENSP00000465813
- H3.3A
- H3F3
- H3F3
- H3.3A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.98 | ||
kinase | 0.98 | ||
transcription factor perturbation | 0.98 | ||
transcription factor binding site profile | 0.97 | ||
kinase perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 191.13 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 501 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 191.13 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 501 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (263)
LACC1
Family: Enzyme
Novelty: 0.03928871
p_int: 0.999999933
p_ni: 6.6e-8
p_wrong: 1e-9
Data Source: BioPlex
SGO2
Novelty: 0.05544423
p_int: 0.999656444
p_ni: 2.93e-7
p_wrong: 0.000343263
Data Source: BioPlex
NASP
Novelty: 0.00902599
p_int: 0.990936769
p_ni: 3.5e-8
p_wrong: 0.009063196
Score: 0.647
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (68)
Reactome (56)
KEGG (3)
PathwayCommons (3)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Amyloid fiber formation | ||||
B-WICH complex positively regulates rRNA expression | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (4)
Components (10)
Processes (26)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 93.3 | |||||
low density lipoprotein cholesterol measurement | 6 | 4 | 6 | 91.7 | |||||
white matter hyperintensity measurement | 3 | 1 | 3 | 81.3 | |||||
eosinophil count | 3 | 2 | 3 | 79 | |||||
mean platelet volume | 1 | 1 | 1 | 72.3 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 93.3 | |||||
low density lipoprotein cholesterol measurement | 6 | 91.7 | |||||
white matter hyperintensity measurement | 3 | 81.3 | |||||
eosinophil count | 3 | 79 | |||||
mean platelet volume | 1 | 72.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1097686 | 15078 | ||||||
Pig | H3 histone, family 3A | 396970 | ||||||
Opossum | H3 histone, family 3B | 100022653 | ||||||
Zebrafish | ZDB-GENE-040426-1928 | 406269 | ||||||
C. elegans | 181057 | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Pig | H3 histone, family 3A | |||||
Opossum | H3 histone, family 3B | |||||
Zebrafish | ||||||
C. elegans | ||||||
Publication Statistics
PubMed Score 191.13
PubMed score by year
PubTator Score 73.68
PubTator score by year
Related Publications
Text Mined References (115)
GeneRif Annotations (46)
Items per page:
0 of 0
PMID | Year | Title |
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