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Tbio
H2BFWT
Histone H2B type W-T

Protein Summary
Description
Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217926
  • ENSP00000354723
  • ENSG00000123569
  • ENST00000611083
  • ENSP00000482103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
cellular component
0.54
tissue
0.47
cell line
0.44
tissue sample
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
H2AFY
Tbio
Novelty:  0.01150729
p_int:  0.999839838
p_ni:  0.000160162
Score:  0.944
Data Source:  BioPlex,STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
p_int:  0.999488183
p_ni:  0.000125302
p_wrong:  0.000386515
Data Source:  BioPlex
XPC
Tbio
Novelty:  0.00775175
p_int:  0.996564024
p_ni:  0.003435976
Data Source:  BioPlex
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.988085074
p_ni:  0.011914926
Data Source:  BioPlex
ARHGEF40
Tdark
Novelty:  0.3458097
p_int:  0.945668801
p_ni:  0.053500861
p_wrong:  0.000830337
Data Source:  BioPlex
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.945305112
p_ni:  0.054694888
Score:  0.235
Data Source:  BioPlex,STRINGDB
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.915608682
p_ni:  0.083636228
p_wrong:  0.00075509
Data Source:  BioPlex
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.90719986
p_ni:  0.092800138
p_wrong:  2e-9
Score:  0.311
Data Source:  BioPlex,STRINGDB
HIST1H2AG
Tbio
Novelty:  0.03331195
p_int:  0.842606902
p_ni:  0.157393098
Score:  0.686
Data Source:  BioPlex,STRINGDB
PARP1
Tclin
Family:  Enzyme
Novelty:  0.00033016
p_int:  0.801662241
p_ni:  0.198337759
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Systemic lupus erythematosus
KEGG
Viral carcinogenesis
KEGG
Alcoholism
Name
Explore in Pharos
Explore in Source
Systemic lupus erythematosus
Viral carcinogenesis
Alcoholism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone H2B type W-T
473712
Macaque
H2B histone family, member W, testis-specific
699275
Dog
H2B histone family, member W, testis-specific
491396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone H2B type W-T
Macaque
H2B histone family, member W, testis-specific
Dog
H2B histone family, member W, testis-specific
Publication Statistics
PubMed Score 6.07
PubMed score by year
PubTator Score 6.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title