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Tbio
H2AFZ
Histone H2A.Z

Protein Summary
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296417
  • ENSP00000296417
  • ENSG00000164032

Symbol
  • H2AZ
  • H2AZ
  • H2A.z
  • H2A/z
  • H2A.Z-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.98
kinase perturbation
0.98
molecular function
0.95
virus perturbation
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.58   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 466   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.58   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 466   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (615)
HIST1H2BO
Tdark
Novelty:  0.3427419
p_int:  0.999999977
p_ni:  2.2e-8
Score:  0.959
Data Source:  BioPlex,STRINGDB
VPS72
Tbio
Novelty:  0.00561093
p_int:  0.999999971
p_ni:  2.3e-8
p_wrong:  6e-9
Score:  0.953
Data Source:  BioPlex,STRINGDB
MIER3
Tdark
Family:  TF
Novelty:  0.42079723
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.277
Data Source:  BioPlex,STRINGDB
PHF14
Tbio
Family:  Epigenetic
Novelty:  0.13279118
p_int:  0.999999857
p_ni:  1.43e-7
Score:  0.343
Data Source:  BioPlex,STRINGDB
HIST1H2BD
Tbio
Novelty:  0.05094332
p_int:  0.999999799
p_ni:  1.5e-8
p_wrong:  1.87e-7
Score:  0.958
Data Source:  BioPlex,STRINGDB
MIER1
Tbio
Novelty:  0.00357772
p_int:  0.999999672
p_ni:  3.28e-7
Score:  0.277
Data Source:  BioPlex,STRINGDB
EPC2
Tbio
Novelty:  0.02760809
p_int:  0.999999306
p_ni:  6.94e-7
Score:  0.283
Data Source:  BioPlex,STRINGDB
RAI1
Tbio
Family:  Epigenetic
Novelty:  0.01088494
p_int:  0.999998964
p_ni:  0.000001035
p_wrong:  2e-9
Score:  0.312
Data Source:  BioPlex,STRINGDB
ARID5B
Tbio
Family:  TF
Novelty:  0.01201607
p_int:  0.999998383
p_ni:  0.000001611
p_wrong:  6e-9
Data Source:  BioPlex
ACTR6
Tbio
Novelty:  0.11005766
p_int:  0.999998256
p_ni:  0.000001744
Score:  0.858
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (84)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Items per page:
1 – 5 of 73
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol use disorder measurement
2
1
0
9
88.6
alcohol consumption measurement
1
1
1
78.1
mean corpuscular volume
1
1
1
57.1
reticulocyte measurement
1
1
1
41.5
total cholesterol measurement
1
1
1
32.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol use disorder measurement
0
9
88.6
alcohol consumption measurement
1
78.1
mean corpuscular volume
1
57.1
reticulocyte measurement
1
41.5
total cholesterol measurement
1
32.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2A histone family, member Z
461400
Macaque
H2A histone family, member Z
709326
Mouse
MGI:1888388
51788
Rat
RGD:621464
58940
Dog
H2A histone family, member Z
478493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2A histone family, member Z
Macaque
H2A histone family, member Z
Mouse
Rat
Dog
H2A histone family, member Z
Publication Statistics
PubMed Score 626.58
PubMed score by year
PubTator Score 212.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title