Protein Summary
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating u ...more
- ENST00000375167
- ENSP00000364310
- ENSG00000188486
- ENST00000530167
- ENSP00000434024
- H2AX
- H2AX
- H2A.X
- H2A/X
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
phosphatase | 1 | ||
transcription factor binding site profile | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1965.88 (req: < 5)
Gene RIFs: 277 (req: <= 3)
Antibodies: 1394 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1965.88 (req: >= 5)
Gene RIFs: 277 (req: > 3)
Antibodies: 1394 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (689)
TONSL
Novelty: 0.07220129
p_int: 0.999999552
p_ni: 4.48e-7
Score: 0.276
Data Source: BioPlex,STRINGDB
HIST1H1C
Novelty: 0.00415337
p_int: 0.999999496
p_ni: 5.04e-7
Score: 0.541
Data Source: BioPlex,STRINGDB
PHF14
Family: Epigenetic
Novelty: 0.13279118
p_int: 0.999999118
p_ni: 8.81e-7
Score: 0.35
Data Source: BioPlex,STRINGDB
MMS22L
Novelty: 0.22570578
p_int: 0.999998215
p_ni: 0.000001785
Score: 0.241
Data Source: BioPlex,STRINGDB
HIST1H1T
Novelty: 0.01039464
p_int: 0.999997748
p_ni: 0.000002252
Score: 0.557
Data Source: BioPlex,STRINGDB
IPO9
Novelty: 0.03978028
p_int: 0.999996262
p_ni: 0.000003738
Score: 0.291
Data Source: BioPlex,STRINGDB
CRAMP1
Novelty: 0.26519971
p_int: 0.999991664
p_ni: 0.000008332
p_wrong: 4e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (97)
Reactome (83)
KEGG (3)
PathwayCommons (2)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Amyloid fiber formation | ||||
B-WICH complex positively regulates rRNA expression | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (5)
Components (13)
Processes (15)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 2 | 2 | 94.6 | |||||
platelet crit | 2 | 2 | 2 | 93.5 | |||||
lymphocyte count | 3 | 3 | 3 | 88.2 | |||||
body mass index | 3 | 3 | 3 | 79.5 | |||||
neutrophil percentage of leukocytes | 2 | 2 | 2 | 75 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean reticulocyte volume | 2 | 94.6 | |||||
platelet crit | 2 | 93.5 | |||||
lymphocyte count | 3 | 88.2 | |||||
body mass index | 3 | 79.5 | |||||
neutrophil percentage of leukocytes | 2 | 75 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | H2A histone family member X | VGNC:12576 | 104001345 | |||||
Mouse | MGI:102688 | 15270 | ||||||
Rat | RGD:1566119 | 500987 | ||||||
Dog | histone H2AX | 489372 | ||||||
Cow | H2A histone family, member X | 531733 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | H2A histone family member X | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone H2AX | |||||
Cow | H2A histone family, member X | |||||
Publication Statistics
PubMed Score 1965.88
PubMed score by year
PubTator Score 1155.88
PubTator score by year
Related Publications
Text Mined References (342)
GeneRif Annotations (277)
Items per page:
0 of 0
PMID | Year | Title |
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