Tbio H2AFX Histone H2AX

Protein Summary

Description

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P16104
• Q4ZGJ7
• Q6IAS5
• H2a/x

Gene Name

• H2AFX

Ensembl ID

• ENST00000375167
• ENSP00000364310
• ENSG00000188486
• ENST00000530167
• ENSP00000434024

Symbol

• H2AX
• H2AX
• H2A.X
• H2A/X

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
chemical	1
hub protein	1
phosphatase	1
transcription factor binding site profile	0.98

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H2ax

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H2ax

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2053.28   (req: < 5)

Gene RIFs: 277   (req: <= 3)

Antibodies: 1394   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2053.28   (req: >= 5)

Gene RIFs: 277   (req: > 3)

Antibodies: 1394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (689)

Explore Interacting Targets

1 – 10 of 689

• See Interactions on String-DB

HIST1H2BD

Tbio

Novelty:  0.05094332

p_int:  1

Score:  0.97

Data Source:  BioPlex,STRINGDB

HIST1H2BO

Tdark

Novelty:  0.3427419

p_int:  1

Score:  0.96

Data Source:  BioPlex,STRINGDB

GON4L

Tbio

Novelty:  0.06166736

p_int:  0.999999856

p_ni:  1.44e-7

Data Source:  BioPlex

TONSL

Tbio

Novelty:  0.07220129

p_int:  0.999999552

p_ni:  4.48e-7

Score:  0.276

Data Source:  BioPlex,STRINGDB

HIST1H1C

Tbio

Novelty:  0.00415337

p_int:  0.999999496

p_ni:  5.04e-7

Score:  0.541

Data Source:  BioPlex,STRINGDB

PHF14

Tbio

Family:  Epigenetic

Novelty:  0.13279118

p_int:  0.999999118

p_ni:  8.81e-7

Score:  0.35

Data Source:  BioPlex,STRINGDB

MMS22L

Tbio

Novelty:  0.22570578

p_int:  0.999998215

p_ni:  0.000001785

Score:  0.241

Data Source:  BioPlex,STRINGDB

HIST1H1T

Tdark

Novelty:  0.01039464

p_int:  0.999997748

p_ni:  0.000002252

Score:  0.557

Data Source:  BioPlex,STRINGDB

IPO9

Tbio

Novelty:  0.03978028

p_int:  0.999996262

p_ni:  0.000003738

Score:  0.291

Data Source:  BioPlex,STRINGDB

CRAMP1

Tdark

Novelty:  0.26519971

p_int:  0.999991664

p_ni:  0.000008332

p_wrong:  4e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (97)

Reactome (83)

KEGG (3)

PathwayCommons (2)

WikiPathways (9)

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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1 – 5 of 83

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Name	Explore in Pharos	Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Amyloid fiber formation	79 targets	R-HSA-977225
B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (5)

Components (13)

Processes (15)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
histone binding	Inferred from Physical Interaction (IPI)	UniProtKB
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
damaged DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (36)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 36

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	21	4	21		89.4
mean reticulocyte volume	EFO_0010701	1	2	2		86
platelet crit	EFO_0007985	2	2	2		84.9
body mass index	EFO_0004340	4	4	4		84
serum albumin measurement	EFO_0004535	3	4	4		83.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 36

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	21		89.4
mean reticulocyte volume	EFO_0010701	2		86
platelet crit	EFO_0007985	2		84.9
body mass index	EFO_0004340	4		84
serum albumin measurement	EFO_0004535	4		83.2

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cell cycle
Chromosome
Complete proteome
DNA damage
DNA recombination
DNA repair
DNA-binding
Host-virus interaction

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
blood protein measurement
body fat percentage
body height
body mass index
calcium measurement
cholesteryl ester measurement
cholesteryl esters:total lipids ratio
coronary artery disease
educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
neoplasm
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	H2A histone family member X	VGNC:12576	104001345
Mouse	H2A histone family, member X	MGI:102688	15270
Rat	H2A histone family, member X	RGD:1566119	500987
Dog	histone H2AX		489372
Cow	H2A histone family, member X		531733

Species	Name	OMA	EggNOG	Inparanoid
Chimp	H2A histone family member X
Mouse	H2A histone family, member X
Rat	H2A histone family, member X
Dog	histone H2AX
Cow	H2A histone family, member X

Publication Statistics

PubMed Score 2053.28

PubMed score by year

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PubTator Score 1155.88

PubTator score by year

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Related Publications

Text Mined References (342)

GeneRif Annotations (277)

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10

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PMID	Year	Title