Protein Summary
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker h ...more
- ENST00000222690
- ENSP00000222690
- ENSG00000105968
- ENST00000308153
- ENSP00000308405
- ENST00000349299
- ENSP00000342714
- ENST00000350771
- ENSP00000340708
- ENST00000381124
- ENSP00000370516
- H2AV
- H2AV
- H2A.Z-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 1 | ||
transcription factor perturbation | 0.98 | ||
co-expressed gene | 0.85 | ||
cellular component | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.63 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.63 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (498)
Nearest Tclin Targets
Pathways (76)
Reactome (71)
KEGG (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Reactome | Base Excision Repair | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
B-WICH complex positively regulates rRNA expression | ||||
Base Excision Repair | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 2 | 2 | 2 | 95.1 | |||||
platelet count | 2 | 2 | 2 | 88.5 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 86.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 86 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 84.6 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 2 | 95.1 | |||||
platelet count | 2 | 88.5 | |||||
mean reticulocyte volume | 1 | 86.4 | |||||
mean corpuscular volume | 1 | 86 | |||||
mean corpuscular hemoglobin concentration | 1 | 84.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | H2A histone family member V | VGNC:14019 | 453664 | |||||
Macaque | histone H2A.V-like | 705636 | ||||||
Mouse | MGI:1924855 | 77605 | ||||||
Rat | RGD:1587865 | 685909 | ||||||
Dog | H2A histone family, member V | 475501 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | H2A histone family member V | |||||
Macaque | histone H2A.V-like | |||||
Mouse | ||||||
Rat | ||||||
Dog | H2A histone family, member V | |||||
Publication Statistics
PubMed Score 25.63
PubMed score by year
PubTator Score 10.66
PubTator score by year
Related Publications
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Text |
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