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Tbio
H2AFJ
Histone H2A.J

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389078
  • ENSP00000373730
  • ENSG00000246705
  • ENST00000544848
  • ENSP00000438553

Symbol
  • H2AJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
cellular component
0.78
cell type or tissue
0.75
small molecule perturbation
0.74
gene perturbation
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.92   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.92   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (360)
HIST1H2BB
Tbio
Novelty:  0.20192804
Score:  0.997
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.995
Data Source:  STRINGDB
HIST1H2AC
Tdark
Novelty:  0.4785744
Score:  0.995
Data Source:  STRINGDB
HIST1H2AH
Tbio
Novelty:  0.09573052
Score:  0.994
Data Source:  STRINGDB
HIST1H2AJ
Tdark
Novelty:  0.70360784
Score:  0.994
Data Source:  STRINGDB
HIST1H2BN
Tbio
Novelty:  0.02592521
Score:  0.988
Data Source:  STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.984
Data Source:  STRINGDB
HIST1H2AA
Tbio
Novelty:  0.04021488
Score:  0.979
Data Source:  STRINGDB
HIST3H3
Tbio
Novelty:  0.04915012
Score:  0.976
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.972
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (80)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 71
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Base Excision Repair
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
B-WICH complex positively regulates rRNA expression
Base Excision Repair
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
1
2
2
67.5
BMI-adjusted hip circumference
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
2
67.5
BMI-adjusted hip circumference
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member J
VGNC:52069
465306
Mouse
MGI:3606192
232440
Rat
RGD:1592176
690795
Dog
H2A histone family, member J
486669
Dog
histone H2A type 2-C
100855593
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member J
Mouse
Rat
Dog
H2A histone family, member J
Dog
histone H2A type 2-C
Publication Statistics
PubMed Score 2.92
PubMed score by year
PubTator Score 8.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title