Tbio H1FOO Histone H1oo

Protein Summary

Description

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• Q8IZA3
• Q86WT7

Gene Name

• H1FOO

Ensembl ID

• ENST00000324382
• ENSP00000319799
• ENSG00000178804
• ENST00000503977
• ENSP00000422964

Symbol

• H1OO
• OSH1
• H1.8
• H1oo
• osH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
cellular component	0.69
gene perturbation	0.62
tissue	0.57
cell line	0.51

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H1oo

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H1oo

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.95   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.95   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (115)

Explore Interacting Targets

1 – 10 of 115

• See Interactions on String-DB

HIST1H1C

Tbio

Novelty:  0.00415337

p_int:  0.999991774

p_ni:  0.000008226

Score:  0.587

Data Source:  BioPlex,STRINGDB

HIST1H1A

Tbio

Novelty:  0.00123818

p_int:  0.999984534

p_ni:  0.000015466

Score:  0.664

Data Source:  BioPlex,STRINGDB

HIST1H2BD

Tbio

Novelty:  0.05094332

p_int:  0.999973984

p_ni:  0.000026013

p_wrong:  4e-9

Score:  0.349

Data Source:  BioPlex,STRINGDB

RPS27A

Tbio

Novelty:  0.00658124

p_int:  0.995210363

p_ni:  0.004784449

p_wrong:  0.000005189

Score:  0.458

Data Source:  BioPlex,STRINGDB

HIST1H1T

Tdark

Novelty:  0.01039464

p_int:  0.994781124

p_ni:  0.005218876

Score:  0.718

Data Source:  BioPlex,STRINGDB

RPL8

Tbio

Novelty:  0.01064076

p_int:  0.993111572

p_ni:  0.006888428

Score:  0.186

Data Source:  BioPlex,STRINGDB

RPL26L1

Tdark

Novelty:  0.75408617

p_int:  0.993030717

p_ni:  0.006969283

Data Source:  BioPlex

NOP2

Tbio

Family:  Enzyme

Novelty:  0.01664777

p_int:  0.988540729

p_ni:  0.011459271

Data Source:  BioPlex

RRS1

Tbio

Novelty:  0.01643671

p_int:  0.972469314

p_ni:  0.027530686

Data Source:  BioPlex

GTPBP4

Tchem

Novelty:  0.00062563

p_int:  0.971821509

p_ni:  0.028178491

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (2)

Components (5)

Processes (9)

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GO Term	Evidence	Assigned by
double-stranded DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nucleosomal DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (12)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	13	19	37		98.8
waist-hip ratio	EFO_0004343	4	15	16		98.8
BMI-adjusted hip circumference	EFO_0008039	3	18	21		98.6
hip circumference	EFO_0005093	3	17	20		98
waist circumference	EFO_0004342	1	9	9		92.8

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	37		98.8
waist-hip ratio	EFO_0004343	16		98.8
BMI-adjusted hip circumference	EFO_0008039	21		98.6
hip circumference	EFO_0005093	20		98
waist circumference	EFO_0004342	9		92.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Chromosome
Complete proteome
Cytoplasm
DNA-binding
Meiosis
Nucleus
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
hip circumference
low density lipoprotein cholesterol measurement
lymphocyte count
mean platelet volume
physical activity measurement
smoking behavior
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	H1 histone family member O oocyte specific	VGNC:14868	738671
Macaque	histone H1oo		702823
Mouse	H1 histone family, member O, oocyte-specific	MGI:2176207	171506
Rat	H1 histone family, member O, oocyte-specific	RGD:1566236	502875
Cow	H1 histone family, member O, oocyte-specific		527400

Species	Name	OMA	EggNOG	Inparanoid
Chimp	H1 histone family member O oocyte specific
Macaque	histone H1oo
Mouse	H1 histone family, member O, oocyte-specific
Rat	H1 histone family, member O, oocyte-specific
Cow	H1 histone family, member O, oocyte-specific

Publication Statistics

PubMed Score 44.95

PubMed score by year

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PubTator Score 23.19

PubTator score by year

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Related Publications

GeneRif Annotations (2)

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0 of 0

PMID	Text