Protein Summary
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucle ...more
- ENST00000324382
- ENSP00000319799
- ENSG00000178804
- ENST00000503977
- ENSP00000422964
- H1OO
- OSH1
- H1.8
- H1oo
- osH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.7 | ||
cellular component | 0.69 | ||
gene perturbation | 0.62 | ||
tissue | 0.57 | ||
cell line | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.95 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 167 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.95 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 167 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (115)
HIST1H1C
Novelty: 0.00415337
p_int: 0.999991774
p_ni: 0.000008226
Score: 0.587
Data Source: BioPlex,STRINGDB
HIST1H1A
Novelty: 0.00123818
p_int: 0.999984534
p_ni: 0.000015466
Score: 0.664
Data Source: BioPlex,STRINGDB
HIST1H2BD
Novelty: 0.05094332
p_int: 0.999973984
p_ni: 0.000026013
p_wrong: 4e-9
Score: 0.349
Data Source: BioPlex,STRINGDB
RPS27A
Novelty: 0.00658124
p_int: 0.995210363
p_ni: 0.004784449
p_wrong: 0.000005189
Score: 0.458
Data Source: BioPlex,STRINGDB
HIST1H1T
Novelty: 0.01039464
p_int: 0.994781124
p_ni: 0.005218876
Score: 0.718
Data Source: BioPlex,STRINGDB
RPL8
Novelty: 0.01064076
p_int: 0.993111572
p_ni: 0.006888428
Score: 0.186
Data Source: BioPlex,STRINGDB
NOP2
Family: Enzyme
Novelty: 0.01664777
p_int: 0.988540729
p_ni: 0.011459271
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (5)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 13 | 19 | 37 | 98.8 | |||||
waist-hip ratio | 4 | 15 | 16 | 98.8 | |||||
BMI-adjusted hip circumference | 3 | 18 | 21 | 98.6 | |||||
hip circumference | 3 | 17 | 20 | 98 | |||||
waist circumference | 1 | 9 | 9 | 92.8 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 37 | 98.8 | |||||
waist-hip ratio | 16 | 98.8 | |||||
BMI-adjusted hip circumference | 21 | 98.6 | |||||
hip circumference | 20 | 98 | |||||
waist circumference | 9 | 92.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | H1 histone family member O oocyte specific | VGNC:14868 | 738671 | |||||
Macaque | histone H1oo | 702823 | ||||||
Mouse | MGI:2176207 | 171506 | ||||||
Rat | RGD:1566236 | 502875 | ||||||
Cow | H1 histone family, member O, oocyte-specific | 527400 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | H1 histone family member O oocyte specific | |||||
Macaque | histone H1oo | |||||
Mouse | ||||||
Rat | ||||||
Cow | H1 histone family, member O, oocyte-specific | |||||
Publication Statistics
PubMed Score 44.95
PubMed score by year
PubTator Score 23.19
PubTator score by year
Related Publications
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Text |
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