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Tbio
H1FOO
Histone H1oo

Protein Summary
Description
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucle ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324382
  • ENSP00000319799
  • ENSG00000178804
  • ENST00000503977
  • ENSP00000422964

Symbol
  • H1OO
  • OSH1
  • H1.8
  • H1oo
  • osH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
cellular component
0.69
gene perturbation
0.62
tissue
0.57
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.95   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.95   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
HIST1H1C
Tbio
Novelty:  0.00415337
p_int:  0.999991774
p_ni:  0.000008226
Score:  0.587
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999984534
p_ni:  0.000015466
Score:  0.664
Data Source:  BioPlex,STRINGDB
HIST1H2BD
Tbio
Novelty:  0.05094332
p_int:  0.999973984
p_ni:  0.000026013
p_wrong:  4e-9
Score:  0.349
Data Source:  BioPlex,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.995210363
p_ni:  0.004784449
p_wrong:  0.000005189
Score:  0.458
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.994781124
p_ni:  0.005218876
Score:  0.718
Data Source:  BioPlex,STRINGDB
RPL8
Tbio
Novelty:  0.01064076
p_int:  0.993111572
p_ni:  0.006888428
Score:  0.186
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.993030717
p_ni:  0.006969283
Data Source:  BioPlex
NOP2
Tbio
Family:  Enzyme
Novelty:  0.01664777
p_int:  0.988540729
p_ni:  0.011459271
Data Source:  BioPlex
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.972469314
p_ni:  0.027530686
Data Source:  BioPlex
GTPBP4
Tchem
Novelty:  0.00062563
p_int:  0.971821509
p_ni:  0.028178491
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
13
19
37
98.8
waist-hip ratio
4
15
16
98.8
BMI-adjusted hip circumference
3
18
21
98.6
hip circumference
3
17
20
98
waist circumference
1
9
9
92.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
37
98.8
waist-hip ratio
16
98.8
BMI-adjusted hip circumference
21
98.6
hip circumference
20
98
waist circumference
9
92.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H1 histone family member O oocyte specific
VGNC:14868
738671
Macaque
histone H1oo
702823
Mouse
MGI:2176207
171506
Rat
RGD:1566236
502875
Cow
H1 histone family, member O, oocyte-specific
527400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H1 histone family member O oocyte specific
Macaque
histone H1oo
Mouse
Rat
Cow
H1 histone family, member O, oocyte-specific
Publication Statistics
PubMed Score 44.95
PubMed score by year
PubTator Score 23.19
PubTator score by year
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Related Publications
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PMID
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