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Tdark
H1FNT
Testis-specific H1 histone

Protein Summary
Description
Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335017
  • ENSP00000334805
  • ENSG00000187166

Symbol
  • HANP1
  • H1.7
  • H1T2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
tissue sample
0.65
cell type or tissue
0.63
cellular component
0.57
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.1   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.1   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
SPATS2
Tdark
Novelty:  0.20594325
p_int:  0.999998917
p_ni:  0.000001082
Data Source:  BioPlex
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.99709928
p_ni:  0.002900426
p_wrong:  2.93e-7
Data Source:  BioPlex
MBLAC1
Tdark
Family:  Enzyme
Novelty:  0.48250122
p_int:  0.996740942
p_ni:  0.000055553
p_wrong:  0.003203504
Score:  0.685
Data Source:  BioPlex,STRINGDB
DHX57
Tdark
Family:  Enzyme
Novelty:  0.8244078
p_int:  0.996623291
p_ni:  0.003376709
Data Source:  BioPlex
ZC3H4
Tbio
Novelty:  0.14897433
p_int:  0.996331997
p_ni:  0.003094679
p_wrong:  0.000573323
Data Source:  BioPlex
TUT7
Tbio
Family:  Enzyme
Novelty:  0.06274003
p_int:  0.994450633
p_ni:  0.005549357
p_wrong:  1e-8
Data Source:  BioPlex
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.990070188
p_ni:  0.009929812
Data Source:  BioPlex
ZNF92
Tbio
Family:  TF
Novelty:  0.05724663
p_int:  0.988302657
p_ni:  0.010983819
p_wrong:  0.000713524
Data Source:  BioPlex
TAF1D
Tdark
Family:  Enzyme
Novelty:  0.26072519
p_int:  0.98824499
p_ni:  0.011218817
p_wrong:  0.000536194
Data Source:  BioPlex
CDK12
Tchem
Family:  Kinase
Novelty:  0.0119925
p_int:  0.987849193
p_ni:  0.012136605
p_wrong:  0.000014201
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
5
5
94.3
hematocrit
1
1
1
81.5
glomerular filtration rate
3
2
2
6
80.6
hemoglobin measurement
1
1
1
79
erythrocyte count
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
5
94.3
hematocrit
1
81.5
glomerular filtration rate
2
6
80.6
hemoglobin measurement
1
79
erythrocyte count
1
68.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H1 histone family member N, testis specific
VGNC:14411
743587
Mouse
MGI:1917319
70069
Rat
RGD:1560024
500928
Dog
H1 histone family member N, testis specific [Source:HGNC Symbol;Acc:HGNC:24893]
Pig
testis-specific H1 histone
100516553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H1 histone family member N, testis specific
Mouse
Rat
Dog
H1 histone family member N, testis specific [Source:HGNC Symbol;Acc:HGNC:24893]
Pig
testis-specific H1 histone
Publication Statistics
PubMed Score 15.10
PubMed score by year
PubTator Score 24.11
PubTator score by year
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Related Publications
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PMID
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