Protein Summary
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
- ENST00000216341
- ENSP00000216341
- ENSG00000100453
- CGL1
- CSPB
- CTLA1
- GRB
- C11
- HLP
- CCPI
- CGL1
- CSPB
- SECT
- CGL-1
- CSP-B
- CTLA1
- CTSGL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 0.98 | ||
cellular component | 0.63 | ||
hub protein | 0.63 | ||
biological process | 0.6 | ||
disease | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1796.39 (req: < 5)
Gene RIFs: 206 (req: <= 3)
Antibodies: 1010 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1796.39 (req: >= 5)
Gene RIFs: 206 (req: > 3)
Antibodies: 1010 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (16)
Protein-Protein Interactions (310)
Nearest Tclin Targets
Pathways (26)
Reactome (8)
KEGG (7)
PathwayCommons (6)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation, myristolyation of BID and translocation to mitochondria | ||||
Reactome | Apoptosis | ||||
Reactome | Intrinsic Pathway for Apoptosis | ||||
Reactome | NOTCH2 intracellular domain regulates transcription | ||||
Reactome | Programmed Cell Death | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation, myristolyation of BID and translocation to mitochondria | ||||
Apoptosis | ||||
Intrinsic Pathway for Apoptosis | ||||
NOTCH2 intracellular domain regulates transcription | ||||
Programmed Cell Death | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 1 | 0 | 1.3 | 65.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.3 | 65.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | granzyme B | VGNC:3410 | 452825 | |||||
Macaque | granzyme B | 716518 | ||||||
Mouse | MGI:109267 | 14939 | ||||||
Rat | RGD:2320502 | 100361261 | ||||||
Dog | granzyme B | VGNC:50530 | 490630 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | granzyme B | |||||
Macaque | granzyme B | |||||
Mouse | ||||||
Rat | ||||||
Dog | granzyme B | |||||
Publication Statistics
PubMed Score 1796.39
PubMed score by year
PubTator Score 1315.51
PubTator score by year
Related Publications
Text Mined References (268)
GeneRif Annotations (206)
Items per page:
0 of 0
PMID | Year | Title |
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