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Tchem
GZMB
Granzyme B

Protein Summary
Description
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216341
  • ENSP00000216341
  • ENSG00000100453

Symbol
  • CGL1
  • CSPB
  • CTLA1
  • GRB
  • C11
  • HLP
  • CCPI
  • CGL1
  • CSPB
  • SECT
  • CGL-1
  • CSP-B
  • CTLA1
  • CTSGL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
cellular component
0.63
hub protein
0.63
biological process
0.6
disease
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1796.39   (req: < 5)
Gene RIFs: 206   (req: <= 3)
Antibodies: 1010   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1796.39   (req: >= 5)
Gene RIFs: 206   (req: > 3)
Antibodies: 1010   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (310)
PRF1
Tchem
Novelty:  0.0002835
Score:  0.999
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.976
Data Source:  STRINGDB
CASP7
Tchem
Family:  Enzyme
Novelty:  0.00126224
Score:  0.965
Data Source:  STRINGDB
BID
Tbio
Novelty:  0.01264688
Score:  0.946
Data Source:  Reactome,STRINGDB
CASP10
Tchem
Family:  Enzyme
Novelty:  0.00724061
Score:  0.944
Data Source:  STRINGDB
GNLY
Tbio
Novelty:  0.00183877
Score:  0.938
Data Source:  STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.931
Data Source:  STRINGDB
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.917
Data Source:  STRINGDB
DFFA
Tbio
Novelty:  0.00253065
Score:  0.915
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Activation, myristolyation of BID and translocation to mitochondria (R-HSA-75108)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation, myristolyation of BID and translocation to mitochondria
Reactome
Apoptosis
Reactome
Intrinsic Pathway for Apoptosis
Reactome
NOTCH2 intracellular domain regulates transcription
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Activation, myristolyation of BID and translocation to mitochondria
Apoptosis
Intrinsic Pathway for Apoptosis
NOTCH2 intracellular domain regulates transcription
Programmed Cell Death
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.3
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
65.3
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
granzyme B
VGNC:3410
452825
Macaque
granzyme B
716518
Mouse
MGI:109267
14939
Rat
RGD:2320502
100361261
Dog
granzyme B
VGNC:50530
490630
Species
Name
OMA
EggNOG
Inparanoid
Chimp
granzyme B
Macaque
granzyme B
Mouse
Rat
Dog
granzyme B
Publication Statistics
PubMed Score 1796.39
PubMed score by year
PubTator Score 1315.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title