Tchem GZMB Granzyme B

Protein Summary

Description

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• P10144
• Q8N1D2
• Q9UCC1

Gene Name

• GZMB

Ensembl ID

• ENST00000216341
• ENSP00000216341
• ENSG00000100453

Symbol

• CGL1
• CSPB
• CTLA1
• GRB
• C11
• HLP
• CCPI
• CGL1
• CSPB
• SECT
• CGL-1
• CSP-B
• CTLA1
• CTSGL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.98
cellular component	0.63
hub protein	0.63
biological process	0.6
disease	0.6

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Granzyme B

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Granzyme B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1796.39   (req: < 5)

Gene RIFs: 206   (req: <= 3)

Antibodies: 1010   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1796.39   (req: >= 5)

Gene RIFs: 206   (req: > 3)

Antibodies: 1010   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (16)

Explore Active Ligands

1 – 10 of 16

CHEMBL304368

GZMBTchem Enzyme

pKi : 6.46

compound 20 [PMID:12127536]

GZMBTchem Enzyme

pKi : 7.58

CHEMBL303031

GZMBTchem Enzyme

pKi : 6.7

CHEMBL69027

GZMBTchem Enzyme

pKi : 6.84

CHEMBL306860

GZMBTchem Enzyme

pKi : 8.15

CHEMBL255387

GZMBTchem Enzyme

pKi : 8.15

CHEMBL428244

GZMBTchem Enzyme

pKi : 8.1

CHEMBL71493

GZMBTchem Enzyme

pKi : 7.89

CHEMBL306381

GZMBTchem Enzyme

pKi : 7.42

CHEMBL303944

GZMBTchem Enzyme

pKi : 7.13

Protein-Protein Interactions (310)

Explore Interacting Targets

1 – 10 of 310

• See Interactions on String-DB

PRF1

Tchem

Novelty:  0.0002835

Score:  0.999

Data Source:  STRINGDB

CASP3

Tchem

Family:  Enzyme

Novelty:  0.00003555

Score:  0.976

Data Source:  STRINGDB

CASP7

Tchem

Family:  Enzyme

Novelty:  0.00126224

Score:  0.965

Data Source:  STRINGDB

BID

Tbio

Novelty:  0.01264688

Score:  0.946

Data Source:  Reactome,STRINGDB

CASP10

Tchem

Family:  Enzyme

Novelty:  0.00724061

Score:  0.944

Data Source:  STRINGDB

GNLY

Tbio

Novelty:  0.00183877

Score:  0.938

Data Source:  STRINGDB

CASP8

Tchem

Family:  Enzyme

Novelty:  0.00024321

Score:  0.931

Data Source:  STRINGDB

CREB1

Tbio

Family:  TF

Novelty:  0.00018059

Score:  0.917

Data Source:  STRINGDB

DFFA

Tbio

Novelty:  0.00253065

Score:  0.915

Data Source:  STRINGDB

NOTCH2

Tchem

Novelty:  0.00195617

Score:  0.912

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (26)

Reactome (8)

KEGG (7)

PathwayCommons (6)

WikiPathways (5)

Activation, myristolyation of BID and translocation to mitochondria (R-HSA-75108)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation, myristolyation of BID and translocation to mitochondria	4 targets	R-HSA-75108
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Intrinsic Pathway for Apoptosis	52 targets	R-HSA-109606
Reactome	NOTCH2 intracellular domain regulates transcription	12 targets	R-HSA-2197563
Reactome	Programmed Cell Death	180 targets	R-HSA-5357801

Name	Explore in Pharos	Explore in Source
Activation, myristolyation of BID and translocation to mitochondria	4 targets	R-HSA-75108
Apoptosis	177 targets	R-HSA-109581
Intrinsic Pathway for Apoptosis	52 targets	R-HSA-109606
NOTCH2 intracellular domain regulates transcription	12 targets	R-HSA-2197563
Programmed Cell Death	180 targets	R-HSA-5357801

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (2)

Components (7)

Processes (5)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
serine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
serine-type peptidase activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Vitiligo	EFO_0004208	2	1	0	1.3	65.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Vitiligo	EFO_0004208	0	1.3	65.3

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UniProt Keyword Find Similar Targets

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3D-structure
Apoptosis
Complete proteome
Cytolysis
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease

GWAS Trait Find Similar Targets

No Header	No Header
Vitiligo

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	granzyme B	VGNC:3410	452825
Macaque	granzyme B		716518
Mouse	granzyme B	MGI:109267	14939
Rat	Granzyme B-like 3	RGD:2320502	100361261
Dog	granzyme B	VGNC:50530	490630

Species	Name	OMA	EggNOG	Inparanoid
Chimp	granzyme B
Macaque	granzyme B
Mouse	granzyme B
Rat	Granzyme B-like 3
Dog	granzyme B

Publication Statistics

PubMed Score 1796.39

PubMed score by year

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PubTator Score 1315.51

PubTator score by year

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Related Publications

Text Mined References (268)

GeneRif Annotations (206)

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PMID	Year	Title