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Tbio
GZMA
Granzyme A

Protein Summary
Description
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274306
  • ENSP00000274306
  • ENSG00000145649

Symbol
  • CTLA3
  • HFSP
  • HFSP
  • CTLA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
tissue sample
0.63
disease
0.61
protein domain
0.58
biological process
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.02   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.02   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
PRF1
Tchem
Novelty:  0.0002835
Score:  0.996
Data Source:  STRINGDB
SET
Tbio
Novelty:  0.01012327
Score:  0.981
Data Source:  STRINGDB
ANP32A
Tbio
Novelty:  0.00567095
Score:  0.974
Data Source:  STRINGDB
NME1
Tbio
Family:  Kinase
Novelty:  0.00103216
Score:  0.973
Data Source:  STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.973
Data Source:  STRINGDB
HMGB2
Tbio
Family:  TF
Novelty:  0.01761676
Score:  0.958
Data Source:  STRINGDB
GNLY
Tbio
Novelty:  0.00183877
Score:  0.923
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.916
Data Source:  STRINGDB
GZMK
Tbio
Family:  Enzyme
Novelty:  0.01355915
Score:  0.916
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.912
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
endothelial cell-specific molecule 1 measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
endothelial cell-specific molecule 1 measurement
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
granzyme A
VGNC:4023
461873
Macaque
granzyme A
705712
Mouse
MGI:109266
14938
Rat
RGD:628640
266708
Dog
granzyme A
VGNC:41577
487207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
granzyme A
Macaque
granzyme A
Mouse
Rat
Dog
granzyme A
Publication Statistics
PubMed Score 277.02
PubMed score by year
PubTator Score 244.28
PubTator score by year
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Related Publications
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PMID
Year
Title