Tbio GZMA Granzyme A

Protein Summary

Description

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P12544
• A4PHN1
• Q6IB36

Gene Name

• GZMA

Ensembl ID

• ENST00000274306
• ENSP00000274306
• ENSG00000145649

Symbol

• CTLA3
• HFSP
• HFSP
• CTLA3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.91
tissue sample	0.63
disease	0.61
protein domain	0.58
biological process	0.54

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Granzyme A

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Granzyme A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.46   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 341   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.46   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0