Tbio GYPB Glycophorin-B

Protein Summary

Description

This protein is a minor sialoglycoprotein in erythrocyte membranes. Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P06028
• B8Q174
• E2QBW7
• Q0VAF4
• Q58HE9
• Q58HF0
• Q58HF1
• Q9UCH7

Gene Name

• GYPB

Ensembl ID

• ENST00000502664
• ENSP00000427690
• ENSG00000250361
• ENST00000513128
• ENSP00000425244

Symbol

• GPB
• SS
• GPB
• GYP
• MNS
• GYPA
• PAS-3
• CD235b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.56
virus perturbation	0.55
co-expressed gene	0.52
small molecule perturbation	0.52
phenotype	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.2   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.2   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0