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Tbio
GYPB
Glycophorin-B

Protein Summary
Description
This protein is a minor sialoglycoprotein in erythrocyte membranes. Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000502664
  • ENSP00000427690
  • ENSG00000250361
  • ENST00000513128
  • ENSP00000425244

Symbol
  • GPB
  • SS
  • GPB
  • GYP
  • MNS
  • GYPA
  • PAS-3
  • CD235b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.56
virus perturbation
0.55
co-expressed gene
0.52
small molecule perturbation
0.52
phenotype
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.09   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.09   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
RANBP17
Tbio
Novelty:  0.12438452
p_int:  1
Score:  0.225
Data Source:  BioPlex,STRINGDB
SMYD4
Tbio
Family:  Epigenetic
Novelty:  0.18455037
p_int:  0.999999437
p_ni:  2.47e-7
p_wrong:  3.16e-7
Score:  0.225
Data Source:  BioPlex,STRINGDB
ESRRA
Tchem
Family:  NR
Novelty:  0.003235
p_int:  0.999998984
p_wrong:  0.000001016
Score:  0.225
Data Source:  BioPlex,STRINGDB
FANCG
Tbio
Novelty:  0.00908902
p_int:  0.999998972
p_ni:  0.000001027
Data Source:  BioPlex
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.999993139
p_ni:  0.000006861
Data Source:  BioPlex
UTP20
Tbio
Novelty:  0.09170451
p_int:  0.999985255
p_ni:  0.000014745
Data Source:  BioPlex
PDS5A
Tbio
Novelty:  0.0142948
p_int:  0.999978062
p_ni:  0.000021938
Data Source:  BioPlex
BZW1
Tbio
Novelty:  0.11677238
p_int:  0.999959239
p_ni:  0.00004076
p_wrong:  1e-9
Data Source:  BioPlex
EIF2B3
Tbio
Novelty:  0.04963646
p_int:  0.999948403
p_ni:  0.000051597
Data Source:  BioPlex
EIF2B4
Tbio
Novelty:  0.05080792
p_int:  0.999946789
p_ni:  0.000053211
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Cell surface interactions at the vascular wall (R-HSA-202733)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
5
10
98.5
reticulocyte measurement
3
4
5
97.8
HbA1c measurement
1
4
4
97.2
mean reticulocyte volume
1
3
3
92.7
mean corpuscular hemoglobin concentration
2
2
2
86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
10
98.5
reticulocyte measurement
5
97.8
HbA1c measurement
4
97.2
mean reticulocyte volume
3
92.7
mean corpuscular hemoglobin concentration
2
86
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 249.09
PubMed score by year
PubTator Score 222.15
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title