Protein Summary
This protein is a minor sialoglycoprotein in erythrocyte membranes. Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000502664
- ENSP00000427690
- ENSG00000250361
- ENST00000513128
- ENSP00000425244
- GPB
- SS
- GPB
- GYP
- MNS
- GYPA
- PAS-3
- CD235b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.56 | ||
virus perturbation | 0.55 | ||
co-expressed gene | 0.52 | ||
small molecule perturbation | 0.52 | ||
phenotype | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 249.09 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 101 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 249.09 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 101 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
SMYD4
Family: Epigenetic
Novelty: 0.18455037
p_int: 0.999999437
p_ni: 2.47e-7
p_wrong: 3.16e-7
Score: 0.225
Data Source: BioPlex,STRINGDB
ESRRA
Family: NR
Novelty: 0.003235
p_int: 0.999998984
p_wrong: 0.000001016
Score: 0.225
Data Source: BioPlex,STRINGDB
TCAF2
Family: Enzyme
Novelty: 0.37070492
p_int: 0.999993139
p_ni: 0.000006861
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (2)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (3)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 5 | 10 | 98.5 | |||||
reticulocyte measurement | 3 | 4 | 5 | 97.8 | |||||
HbA1c measurement | 1 | 4 | 4 | 97.2 | |||||
mean reticulocyte volume | 1 | 3 | 3 | 92.7 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 86 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte count | 10 | 98.5 | |||||
reticulocyte measurement | 5 | 97.8 | |||||
HbA1c measurement | 4 | 97.2 | |||||
mean reticulocyte volume | 3 | 92.7 | |||||
mean corpuscular hemoglobin concentration | 2 | 86 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 249.09
PubMed score by year
PubTator Score 222.15
PubTator score by year
Related Publications
Text Mined References (54)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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