Tbio GYPA Glycophorin-A

Protein Summary

Description

Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02724
• A8K3E6
• B8Q182
• B8Q185
• Q9BS51

Gene Name

• GYPA

Ensembl ID

• ENST00000324022
• ENSP00000324483
• ENSG00000170180
• ENST00000642713
• ENSP00000494092
• ENST00000646447
• ENSP00000495922

Symbol

• GPA
• MN
• GPA
• MNS
• GPSAT
• PAS-2
• CD235a
• GPErik
• HGpMiV
• HGpMiXI
• HGpSta(C)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.76
cellular component	0.62
disease	0.59
microRNA	0.59
chemical	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1423.02   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 1867   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1423.02   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 1867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (101)

Explore Interacting Targets

1 – 10 of 101

• See Interactions on String-DB

ATR

Tchem

Family:  Kinase

Novelty:  0.00196978

p_int:  0.999972958

p_ni:  0.000027042

Data Source:  BioPlex

CLDND1

Tbio

Novelty:  0.06681793

p_int:  0.999373195

p_ni:  0.000542726

p_wrong:  0.000084079

Score:  0.392

Data Source:  BioPlex,STRINGDB

TMEM192

Tbio

Novelty:  0.30699087

p_int:  0.995918615

p_ni:  0.004081384

Score:  0.183

Data Source:  BioPlex,STRINGDB

GOLGA7

Tbio

Novelty:  0.17108842

p_int:  0.995696641

p_ni:  0.004267111

p_wrong:  0.000036248

Score:  0.686

Data Source:  BioPlex,STRINGDB

TCAF2

Tbio

Family:  Enzyme

Novelty:  0.37070492

p_int:  0.993668862

p_ni:  0.006329421

p_wrong:  0.000001716

Data Source:  BioPlex

EEF1A2

Tchem

Novelty:  0.001472

p_int:  0.943121942

p_ni:  0.056878058

Data Source:  BioPlex

SLC22A18

Tbio

Family:  Transporter

Novelty:  0.0189809

p_int:  0.914290946

p_ni:  0.085708986

p_wrong:  6.8e-8

Data Source:  BioPlex

STAT2

Tbio

Family:  TF

Novelty:  0.00241454

p_int:  0.840693727

p_ni:  0.147736785

p_wrong:  0.011569489

Score:  0.189

Data Source:  BioPlex,STRINGDB

DNM3

Tbio

Novelty:  0.02365643

p_int:  0.832405476

p_ni:  0.167594524

Data Source:  BioPlex

NEMF

Tbio

Novelty:  0.05052246

p_int:  0.831005906

p_ni:  0.168994094

Score:  0.189

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (30)

Reactome (2)

KEGG (2)

WikiPathways (26)

Cell surface interactions at the vascular wall (R-HSA-202733)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (2)

Components (3)

Processes (1)

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GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
virus receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (16)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	1	5	5		98
mean reticulocyte volume	EFO_0010701	1	3	3		93.4
monocyte count	EFO_0005091	2	2	2		91.1
mean corpuscular hemoglobin concentration	EFO_0004528	2	2	2		86
reticulocyte measurement	EFO_0010700	2	2	3		79.9

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	5		98
mean reticulocyte volume	EFO_0010701	3		93.4
monocyte count	EFO_0005091	2		91.1
mean corpuscular hemoglobin concentration	EFO_0004528	2		86
reticulocyte measurement	EFO_0010700	3		79.9

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Blood group antigen
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
bilirubin measurement
BMI-adjusted hip circumference
erythrocyte count
HbA1c measurement
leukocyte count
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume
monocyte count
myeloid white cell count

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype

IDG Resources

No IDG generated resources found

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glycophorin A (MNS blood group)		461520

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glycophorin A (MNS blood group)

Publication Statistics

PubMed Score 1423.02

PubMed score by year

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PubTator Score 1076.85

PubTator score by year

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Related Publications

Text Mined References (93)

GeneRif Annotations (39)

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PMID	Year	Title