Protein Summary
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isofor ...more
- ENST00000324022
- ENSP00000324483
- ENSG00000170180
- ENST00000642713
- ENSP00000494092
- ENST00000646447
- ENSP00000495922
- GPA
- MN
- GPA
- MNS
- GPSAT
- PAS-2
- CD235a
- GPErik
- HGpMiV
- HGpMiXI
- HGpSta(C)
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.76 | ||
cellular component | 0.62 | ||
disease | 0.59 | ||
microRNA | 0.59 | ||
chemical | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1423.02 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 1867 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1423.02 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 1867 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (101)
ATR
Family: Kinase
Novelty: 0.00196978
p_int: 0.999972958
p_ni: 0.000027042
Data Source: BioPlex
CLDND1
Novelty: 0.06681793
p_int: 0.999373195
p_ni: 0.000542726
p_wrong: 0.000084079
Score: 0.392
Data Source: BioPlex,STRINGDB
TMEM192
Novelty: 0.30699087
p_int: 0.995918615
p_ni: 0.004081384
Score: 0.183
Data Source: BioPlex,STRINGDB
GOLGA7
Novelty: 0.17108842
p_int: 0.995696641
p_ni: 0.004267111
p_wrong: 0.000036248
Score: 0.686
Data Source: BioPlex,STRINGDB
TCAF2
Family: Enzyme
Novelty: 0.37070492
p_int: 0.993668862
p_ni: 0.006329421
p_wrong: 0.000001716
Data Source: BioPlex
SLC22A18
Family: Transporter
Novelty: 0.0189809
p_int: 0.914290946
p_ni: 0.085708986
p_wrong: 6.8e-8
Data Source: BioPlex
STAT2
Family: TF
Novelty: 0.00241454
p_int: 0.840693727
p_ni: 0.147736785
p_wrong: 0.011569489
Score: 0.189
Data Source: BioPlex,STRINGDB
NEMF
Novelty: 0.05052246
p_int: 0.831005906
p_ni: 0.168994094
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (30)
Reactome (2)
KEGG (2)
WikiPathways (26)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 1 | 5 | 5 | 98 | |||||
mean reticulocyte volume | 1 | 3 | 3 | 93.4 | |||||
monocyte count | 2 | 2 | 2 | 91.1 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 86 | |||||
reticulocyte measurement | 2 | 2 | 3 | 79.9 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
HbA1c measurement | 5 | 98 | |||||
mean reticulocyte volume | 3 | 93.4 | |||||
monocyte count | 2 | 91.1 | |||||
mean corpuscular hemoglobin concentration | 2 | 86 | |||||
reticulocyte measurement | 3 | 79.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | glycophorin A (MNS blood group) | 461520 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | glycophorin A (MNS blood group) | |||||
Publication Statistics
PubMed Score 1423.02
PubMed score by year
PubTator Score 1076.85
PubTator score by year
Related Publications
Text Mined References (93)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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