Tbio GXYLT2 Glucoside xylosyltransferase 2

Protein Summary

Description

Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. The protein encoded by this gene is a xylosyltransferase that elongates O-linked glucose bound to epidermal growth factor (EGF) repeats. The encoded protein catalyzes the addition of xylose to the O-glucose-modified residues of EGF repeats of Notch proteins. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• A0PJZ3

Gene Name

• GXYLT2

Ensembl ID

• ENST00000389617
• ENSP00000374268
• ENSG00000172986

Symbol

• GLT8D4
• GLT8D4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.93
gene perturbation	0.76
histone modification site profile	0.68
transcription factor perturbation	0.68
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.19   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.19   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0