Tchem GUSB Beta-glucuronidase

Protein Summary

Description

Plays an important role in the degradation of dermatan and keratan sulfates. This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]

Uniprot Accession IDs

• P08236
• B4E1F6
• E9PCV0
• Q549U0
• Q96CL9

Gene Name

• GUSB

Ensembl ID

• ENST00000304895
• ENSP00000302728
• ENSG00000169919
• ENST00000421103
• ENSP00000391390

Symbol

• BG
• MPS7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
protein domain	1
virus perturbation	1
transcription factor perturbation	0.94
pathway	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1677.8   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 354   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1677.8   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0