Protein Summary
Plays an important role in the degradation of dermatan and keratan sulfates. This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]
- ENST00000304895
- ENSP00000302728
- ENSG00000169919
- ENST00000421103
- ENSP00000391390
- BG
- MPS7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
protein domain | 1 | ||
virus perturbation | 1 | ||
transcription factor perturbation | 0.94 | ||
pathway | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1430.96 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 354 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1430.96 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 354 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 41
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (41)
Protein-Protein Interactions (233)
HOXA3
Family: TF
Novelty: 0.01407069
p_int: 0.999930799
p_wrong: 0.000069201
Score: 0.688
Data Source: BioPlex,STRINGDB
PMEL
Novelty: 0.00116525
p_int: 0.999457311
p_ni: 0.000542688
Score: 0.208
Data Source: BioPlex,STRINGDB
CDK4
Family: Kinase
Novelty: 0.00036742
p_int: 0.989904983
p_ni: 0.010095017
Score: 0.241
Data Source: BioPlex,STRINGDB
IDS
Family: Enzyme
Novelty: 0.00733996
p_int: 0.847783834
p_ni: 0.152216166
Score: 0.722
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (21)
Reactome (15)
KEGG (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Glycosaminoglycan metabolism | ||||
Reactome | HS-GAG degradation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Glycosaminoglycan metabolism | ||||
HS-GAG degradation | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (4)
Components (8)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 1 | 1 | 1 | 60.2 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 13.3 | |||||
glomerular filtration rate | 1 | 1 | 1 | 12.7 | |||||
corneal topography | 1 | 1 | 1 | 6.1 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 1 | 60.2 | |||||
alkaline phosphatase measurement | 1 | 13.3 | |||||
glomerular filtration rate | 1 | 12.7 | |||||
corneal topography | 1 | 6.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glucuronidase beta | VGNC:8690 | 463443 | |||||
Mouse | MGI:95872 | 110006 | ||||||
Rat | RGD:2772 | 24434 | ||||||
Dog | glucuronidase beta | VGNC:54034 | 403831 | |||||
Horse | glucuronidase beta | VGNC:51148 | 100037416 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glucuronidase beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | glucuronidase beta | |||||
Horse | glucuronidase beta | |||||
Publication Statistics
PubMed Score 1430.96
PubMed score by year
PubTator Score 2154.95
PubTator score by year
Related Publications
Text Mined References (62)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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