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Tbio
GUK1
Guanylate kinase

Protein Summary
Description
Essential for recycling GMP and indirectly, cGMP. The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312726
  • ENSP00000317659
  • ENSG00000143774
  • ENST00000366716
  • ENSP00000355677
  • ENST00000366718
  • ENSP00000355679
  • ENST00000366726
  • ENSP00000355687
  • ENST00000366728
  • ENSP00000355689
  • ENST00000366730
  • ENSP00000355691
  • ENST00000391865
  • ENSP00000375738

Symbol
  • GMK
  • GMK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
molecular function
0.91
biological process
0.81
kinase perturbation
0.81
transcription factor
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.24   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.24   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0