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Tbio
GUCY2F
Retinal guanylyl cyclase 2

Protein Summary
Description
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218006
  • ENSP00000218006
  • ENSG00000101890

Symbol
  • GUC2F
  • RETGC2
  • CYGF
  • GC-F
  • GUC2F
  • GUC2DL
  • RETGC-2
  • ROS-GC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.99
co-expressed gene
0.95
biological process
0.73
interacting protein
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.04   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.04   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
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The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.993
Data Source:  STRINGDB
GUCA1B
Tbio
Family:  Enzyme
Novelty:  0.02031715
Score:  0.986
Data Source:  STRINGDB
GUCA1C
Tdark
Family:  Enzyme
Novelty:  0.25914047
Score:  0.961
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.9
Data Source:  STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.9
Data Source:  STRINGDB
PDE5A
Tclin
Family:  Enzyme
Novelty:  0.00032205
Score:  0.854
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.819
Data Source:  STRINGDB
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.813
Data Source:  STRINGDB
CNGB3
Tchem
Family:  IC
Novelty:  0.01174942
Score:  0.813
Data Source:  STRINGDB
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.809
Data Source:  STRINGDB
Nearest Tclin Targets (14)
Explore Nearest Tclin Targets
1 – 5 of 14
PDE5A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1C
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6H
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6G
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  3
Pathways (13)
G alpha (i) signalling events (R-HSA-418594)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 2F, retinal
465806
Macaque
guanylate cyclase 2F, retinal
704485
Mouse
MGI:105119
245650
Rat
RGD:620439
116556
Dog
guanylate cyclase 2F, retinal
481016
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 2F, retinal
Macaque
guanylate cyclase 2F, retinal
Mouse
Rat
Dog
guanylate cyclase 2F, retinal
Publication Statistics
PubMed Score 21.04
PubMed score by year
PubTator Score 12.24
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title