Tbio GUCY2D Retinal guanylyl cyclase 1

Protein Summary

Description

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q02846
• Q6LEA7
• RETGC-1

Gene Name

• GUCY2D

Ensembl ID

• ENST00000254854
• ENSP00000254854
• ENSG00000132518

Symbol

• CORD6
• GUC1A4
• GUC2D
• RETGC
• RETGC1
• LCA
• CYGD
• LCA1
• RCD2
• CACD1
• CORD5
• CORD6
• GUC2D
• ROSGC
• retGC
• GUC1A4
• RETGC-1
• ROS-GC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.98
cell type or tissue	0.92
biological process	0.73
biological term	0.61

Protein Classes

PANTHER Classes

Protein / Lyase / Cyclase / Guanylate Cyclase / Retinal Guanylyl Cyclase 1

Protein / Lyase / Cyclase / Adenylate Cyclase / Retinal Guanylyl Cyclase 1

DTO Classes

Protein / Kinase / Protein Kinase / Rgc Group / Rgc Family / Retinal Guanylyl Cyclase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.85   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.85   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0